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dc.contributor.authorSoran, Z.en_US
dc.contributor.authorAydin, R.S.T.en_US
dc.contributor.authorGumusderelioglu, M.en_US
dc.date.accessioned2016-02-08T09:42:57Z
dc.date.available2016-02-08T09:42:57Z
dc.date.issued2012en_US
dc.identifier.issn0265-2048
dc.identifier.urihttp://hdl.handle.net/11693/21201
dc.description.abstractThe aim of this study is to develop an effective growth factor releasing scaffold-microsphere system for promoting periodontal tissue engineering. Bone morphogenetic protein-6 (BMP-6)-loaded alginate microspheres in narrow size distribution were produced by optimising electrospraying conditions. The addition of these microspheres to chitosan gels produced a novel scaffold in which not only the pore sizes and interconnectivity were preserved, but also a controlled release vehicle was generated. Loading capacity was adjusted as 50ng or 100ng BMP-6 for each scaffold and the controlled release behaviour of BMP-6 from chitosan scaffolds was observed during seven days. Cell culture studies were carried out with rat mesenchymal stem cells derived from bone marrow in three groups; chitosan scaffolds, chitosan scaffolds containing BMP-6-loaded alginate microspheres and chitosan scaffolds with free BMP-6 in culture medium. Results showed that controlled delivery of BMP-6 from alginate microspheres has a significant effect on osteogenic differentiation. © 2012 Informa UK Ltd All rights reserved.en_US
dc.language.isoEnglishen_US
dc.source.titleJournal of Microencapsulationen_US
dc.relation.isversionofhttp://dx.doi.org/10.3109/02652048.2012.686531en_US
dc.subjectAlginate microspheresen_US
dc.subjectBMP-6en_US
dc.subjectChitosan scaffolden_US
dc.subjectMesenchymal stem cellsen_US
dc.subjectPeriodontal tissue engineeringen_US
dc.subjectalginic aciden_US
dc.subjectbone morphogenetic protein 6en_US
dc.subjectchitosanen_US
dc.subjectmicrosphereen_US
dc.subjectanimal cellen_US
dc.subjectarticleen_US
dc.subjectbone marrowen_US
dc.subjectcell cultureen_US
dc.subjectcell differentiationen_US
dc.subjectcontrolled release formulationen_US
dc.subjectculture mediumen_US
dc.subjectdrug releaseen_US
dc.subjectelectrosprayen_US
dc.subjectmesenchymal stem cellen_US
dc.subjectnonhumanen_US
dc.subjectperiodontiumen_US
dc.subjectraten_US
dc.subjecttissue engineeringen_US
dc.subjectAlginatesen_US
dc.subjectAnimalsen_US
dc.subjectBone Morphogenetic Protein 6en_US
dc.subjectChitosanen_US
dc.subjectCulture Mediaen_US
dc.subjectGlucuronic Aciden_US
dc.subjectHexuronic Acidsen_US
dc.subjectMesenchymal Stromal Cellsen_US
dc.subjectMicroscopy, Electron, Scanningen_US
dc.subjectMicrospheresen_US
dc.subjectPeriodontiumen_US
dc.subjectRatsen_US
dc.subjectTissue Engineeringen_US
dc.titleChitosan scaffolds with BMP-6 loaded alginate microspheres for periodontal tissue engineeringen_US
dc.typeArticleen_US
dc.departmentDepartment of Chemistryen_US
dc.citation.spage770en_US
dc.citation.epage780en_US
dc.citation.volumeNumber29en_US
dc.citation.issueNumber8en_US
dc.identifier.doi10.3109/02652048.2012.686531en_US


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