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      Chitosan scaffolds with BMP-6 loaded alginate microspheres for periodontal tissue engineering

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      Author
      Soran, Z.
      Aydin, R.S.T.
      Gumusderelioglu, M.
      Date
      2012
      Source Title
      Journal of Microencapsulation
      Print ISSN
      0265-2048
      Volume
      29
      Issue
      8
      Pages
      770 - 780
      Language
      English
      Type
      Article
      Item Usage Stats
      127
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      139
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      Abstract
      The aim of this study is to develop an effective growth factor releasing scaffold-microsphere system for promoting periodontal tissue engineering. Bone morphogenetic protein-6 (BMP-6)-loaded alginate microspheres in narrow size distribution were produced by optimising electrospraying conditions. The addition of these microspheres to chitosan gels produced a novel scaffold in which not only the pore sizes and interconnectivity were preserved, but also a controlled release vehicle was generated. Loading capacity was adjusted as 50ng or 100ng BMP-6 for each scaffold and the controlled release behaviour of BMP-6 from chitosan scaffolds was observed during seven days. Cell culture studies were carried out with rat mesenchymal stem cells derived from bone marrow in three groups; chitosan scaffolds, chitosan scaffolds containing BMP-6-loaded alginate microspheres and chitosan scaffolds with free BMP-6 in culture medium. Results showed that controlled delivery of BMP-6 from alginate microspheres has a significant effect on osteogenic differentiation. © 2012 Informa UK Ltd All rights reserved.
      Keywords
      Alginate microspheres
      BMP-6
      Chitosan scaffold
      Mesenchymal stem cells
      Periodontal tissue engineering
      alginic acid
      bone morphogenetic protein 6
      chitosan
      microsphere
      animal cell
      article
      bone marrow
      cell culture
      cell differentiation
      controlled release formulation
      culture medium
      drug release
      electrospray
      mesenchymal stem cell
      nonhuman
      periodontium
      rat
      tissue engineering
      Alginates
      Animals
      Bone Morphogenetic Protein 6
      Chitosan
      Culture Media
      Glucuronic Acid
      Hexuronic Acids
      Mesenchymal Stromal Cells
      Microscopy, Electron, Scanning
      Microspheres
      Periodontium
      Rats
      Tissue Engineering
      Permalink
      http://hdl.handle.net/11693/21201
      Published Version (Please cite this version)
      http://dx.doi.org/10.3109/02652048.2012.686531
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      • Department of Chemistry 635
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