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dc.contributor.authorGurkan-Alp, A. S.en_US
dc.contributor.authorMumcuoglu, M.en_US
dc.contributor.authorAndac, C. A.en_US
dc.contributor.authorDayanc, E.en_US
dc.contributor.authorCetin Atalay, R.en_US
dc.contributor.authorBuyukbingol, E.en_US
dc.date.accessioned2016-02-08T09:42:45Z
dc.date.available2016-02-08T09:42:45Z
dc.date.issued2012en_US
dc.identifier.issn0223-5234
dc.identifier.urihttp://hdl.handle.net/11693/21191
dc.description.abstractIn this study, novel (E)-3-(5-substituted-1H-indol-3-yl)-1-(5,5,8,8- tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one (5(a-e)) derivatives were synthesized and their anticancer effects were determined in vitro. Novel indole retinoid compounds except 5e have anti-proliferative capacity in liver, breast and colon cancer cell lines. This anti-proliferative effect was further analyzed in breast cancer cell line panel by using the most potent compound 5a. It was determined that 5a can inhibit proliferation at very low IC50 concentrations in all of the breast cancer cell lines. Here, we present some evidence on apoptotic termination of cancer cell proliferation which may be primarily driven by the inhibition of RXRα and, to a lesser extent, RXRγ. © 2012 Elsevier Masson SAS. All rights reserved.en_US
dc.language.isoEnglishen_US
dc.source.titleEuropean Journal of Medicinal Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.ejmech.2012.10.013en_US
dc.subjectIndoleen_US
dc.subjectMDA-MB-231en_US
dc.subjectMolecular dynamicsen_US
dc.subjectRetinoiden_US
dc.subjectT47Den_US
dc.titleSynthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivativesen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.citation.spage346en_US
dc.citation.epage354en_US
dc.citation.volumeNumber58en_US
dc.identifier.doi10.1016/j.ejmech.2012.10.013en_US
dc.publisherElsevieren_US


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