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      β-Tubulin mRNA expression profiles during long-term memory formation in classically conditioned C. elegans

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      Author
      Erdoğan, Mutlu
      Şahin, E.
      Date
      2013
      Source Title
      Journal of Neurological Sciences
      Print ISSN
      1300-1817
      Publisher
      Ege Üniversitesi
      Volume
      30
      Issue
      2
      Pages
      296 - 304
      Language
      English; Turkish
      Type
      Article
      Item Usage Stats
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      Abstract
      We report on the mRNA expression profiles of β-tubulin genes in Caenorhabditis elegans during the process of classical conditioning, a type of associative learning. In this research, based on the model that suggests the formation of new synaptic connections for long-term memory storage by means of cytoskeletal rearrangement, we measure the expressional changes on the β-tubulin mRNA levels via quantitative real-time PCR. Using this method, we find that β-tubulin mRNA levels do not significantly change in C. elegans during classical conditioning and long-term memory formation process.
      Keywords
      C. elegans
      Classical conditioning
      Learning
      Long-term memory
      Memory
      Tubulin
      Beta tubulin
      Animal experiment
      Caenorhabditis elegans
      Chemotaxis
      Conditioning
      Controlled study
      Long term memory
      Nerve cell plasticity
      Nonhuman
      Protein expression
      Real time polymerase chain reaction
      RNA isolation
      Sensory nerve cell
      Spectrophotometry
      Permalink
      http://hdl.handle.net/11693/20901
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