Design and fabrication of a microfluidic device for synthesis of chitosan nanoparticles
Author
Cetin, B.
Asik, M. D.
Taze, S.
Date
2013Source Title
Journal of Nanotechnology in Engineering and Medicine
Print ISSN
1949-2944
Volume
4
Issue
3
Language
English
Type
ArticleItem Usage Stats
121
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125
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Abstract
Chitosan nanoparticles have a biodegradable, biocompatible, nontoxic structure, and are commonly used for drug delivery systems. In this study, design, modeling, and fabrication methodology of a microfluidic device for the synthesis of chitosan nanoparticles is presented. In the modeling, 2D flow and concentration field is computed using COMSOL Multiphysics® simulation environment to predict the performance of the device. The microfluidic chip is fabricated out of PDMS. The fabrication of the mold for the microfluidic device is performed using high-precision micromachining. Some preliminary proof-of-concept experiments were performed. It was observed that compared to conventional batch-type methods, the proposed microfluidic device can perform the synthesis much faster and in a much automated and convenient manner. Copyright © 2013 by ASME.