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      • Department of Mechanical Engineering
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      Design and fabrication of a microfluidic device for synthesis of chitosan nanoparticles

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      Author
      Cetin, B.
      Asik, M. D.
      Taze, S.
      Date
      2013
      Source Title
      Journal of Nanotechnology in Engineering and Medicine
      Print ISSN
      1949-2944
      Volume
      4
      Issue
      3
      Language
      English
      Type
      Article
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      Abstract
      Chitosan nanoparticles have a biodegradable, biocompatible, nontoxic structure, and are commonly used for drug delivery systems. In this study, design, modeling, and fabrication methodology of a microfluidic device for the synthesis of chitosan nanoparticles is presented. In the modeling, 2D flow and concentration field is computed using COMSOL Multiphysics® simulation environment to predict the performance of the device. The microfluidic chip is fabricated out of PDMS. The fabrication of the mold for the microfluidic device is performed using high-precision micromachining. Some preliminary proof-of-concept experiments were performed. It was observed that compared to conventional batch-type methods, the proposed microfluidic device can perform the synthesis much faster and in a much automated and convenient manner. Copyright © 2013 by ASME.
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      http://hdl.handle.net/11693/20877
      Published Version (Please cite this version)
      http://dx.doi.org/10.1115/1.4026287
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