Design and fabrication of a microfluidic device for synthesis of chitosan nanoparticles

Date

2013

Authors

Cetin, B.
Asik, M. D.
Taze, S.

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Abstract

Chitosan nanoparticles have a biodegradable, biocompatible, nontoxic structure, and are commonly used for drug delivery systems. In this study, design, modeling, and fabrication methodology of a microfluidic device for the synthesis of chitosan nanoparticles is presented. In the modeling, 2D flow and concentration field is computed using COMSOL Multiphysics® simulation environment to predict the performance of the device. The microfluidic chip is fabricated out of PDMS. The fabrication of the mold for the microfluidic device is performed using high-precision micromachining. Some preliminary proof-of-concept experiments were performed. It was observed that compared to conventional batch-type methods, the proposed microfluidic device can perform the synthesis much faster and in a much automated and convenient manner. Copyright © 2013 by ASME.

Source Title

Journal of Nanotechnology in Engineering and Medicine

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Citation

Published Version (Please cite this version)

Language

English