Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro - Behçet's disease
Güre, A. O.
Demir, G. A.
Journal of Neuroimmunology
1872-8421 (online)0165-5728 (print)
139 - 144
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Please cite this item using this persistent URLhttp://hdl.handle.net/11693/20761
Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. © 2013 Elsevier B.V.