Functional subdomains within human FFA
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/20752
Journal of Neuroscience
- Research Paper 
The fusiform face area (FFA) is a well-studied human brain region that shows strong activation for faces. In functional MRI studies, FFA is often assumed to be a homogeneous collection of voxels with similar visual tuning. To test this assumption, we used natural movies and a quantitative voxelwise modeling and decoding framework to estimate category tuning profiles for individual voxels within FFA. We find that the responses in most FFA voxels are strongly enhanced by faces, as reported in previous studies. However, we also find that responses of individual voxels are selectively enhanced or suppressed by a wide variety of other categories and that these broader tuning profiles differ across FFA voxels. Cluster analysis of category tuning profiles across voxels reveals three spatially segregated functional subdomains within FFA. These subdomains differ primarily in their responses for nonface categories, such as animals, vehicles, and communication verbs. Furthermore, this segregation does not depend on the statistical threshold used to define FFA from responses to functional localizers. These results suggest that voxels within FFA represent more diverse information about object and action categories than generally assumed. © 2013 the authors.
Showing items related by title, author, creator and subject.
Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth Senturk, S.; Mumcuoglu, M.; Gursoy-Yuzugullu O.; Cingoz, B.; Akcali, K.C.; Ozturk, M. (2010)Senescence induction could be used as an effective treatment for hepatocellular carcinoma (HCC). However, major senescence inducers (p53 and p16Ink4a) are frequently inactivated in these cancers.We tested whether transforming ...
Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2,-2B and SPANX-B, during mesenchymal-to-epithelial transition Yilmaz-Ozcan, S.; Sade, A.; Kucukkaraduman, B.; Kaygusuz, Y.; Senses, K.M.; Banerjee, S.; Gure, A.O. (Public Library of Science, 2014)Cancer-testis (CT) genes are expressed in various cancers but not in normal tissues other than in cells of the germline. Although DNA demethylation of promoter-proximal CpGs of CT genes is linked to their expression in ...
Quantification of SLIT-ROBO transcripts in hepatocellular carcinoma reveals two groups of genes with coordinate expression Avci, M.E.; Konu O.; Yagci, T. (2008)Background: SLIT-ROBO families of proteins mediate axon pathfinding and their expression is not solely confined to nervous system. Aberrant expression of SLIT-ROBO genes was repeatedly shown in a wide variety of cancers, ...