Photosensitizers for photodynamic action and synthesis of modules for a molecular demultiplexer
Embargo Lift Date: 2016-09-01
Akkaya, Engin U.
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Photodynamic therapy (PDT) is a new therapeutic methodology that uses light as a distinguishing tool for the treatment of diseased cells. In recent years PDT has become one of the most preferred therapies because it is innocent for the healthy cells and tissues while diagnosing and curing the malignant cells and tissues. Bodipy is one of the most favorite fluorophore in this field due to its excellent chemical and physical properties. Logic gates are widely used in modern technology as the fundamentals of logical operations for the development of science. The progressive advances leads to the emergence and growth of molecular logic gates. Molecular logic gates can be used for the diagnosis and therapies of disease which are originated from the heredity. In addition, they occupy an important place in the theoretical and practical use of photodynamic therapy. In the first part of my thesis, we designed and synthesized a calixarene-Bodipy conjugate molecule as a carrier for the photodynamic therapy agents. It is an amphiphilic delivery molecule that is utilized for the curing of tumor tissues. In the second part, we synthesized modules for molecular logic gate function, DEMUX (demultiplexer), serving as a theranostic device which selects either singlet oxygen channel or energy transfer between the modules depending on the inputs. The superiority of the project is that it serves a realistic pathway for the PDT.