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      Tetrastyryl-BODIPY dyes as potential photosensitizers for photodynamic theraphy

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      Author
      Yeşilgül, Nisa
      Advisor
      Akkaya, Engin U.
      Date
      2011
      Publisher
      Bilkent University
      Language
      English
      Type
      Thesis
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      Abstract
      Photodynamic therapy (PDT) is a novel methodology for a wide range of treatments of cancerous and noncancerous diseases. Success of treatment and photodynamic action is highly dependent the performance of PDT agents. Therefore, PDT agents with unique photophysical properties are required in clinical applications. There are several photosensitizers in literature and some are available. However, most of them less than ideal due to limitations such as low molar absorptivity and photo stabilities. In this study, we synthesized near-IR tetrastyryl-Bodipy derivatives as photosensitizers. These sensitizers have strong absorption in therapeutic region and are good photo-generator of singlet oxygen. They are promising for photodynamic therapy with their favorable properties.
      Keywords
      Boradiazaindacene (Bodipy)
      Photodynamic therapy (PDT)
      Photosensitizer (PS)
      Singlet oxygen
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      http://hdl.handle.net/11693/15758
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      • Dept. of Chemistry - Master's degree 129
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