Tetrastyryl-BODIPY dyes as potential photosensitizers for photodynamic theraphy
Author
Yeşilgül, Nisa
Advisor
Akkaya, Engin U.
Date
2011Publisher
Bilkent University
Language
English
Type
ThesisItem Usage Stats
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Abstract
Photodynamic therapy (PDT) is a novel methodology for a wide range of
treatments of cancerous and noncancerous diseases. Success of treatment and
photodynamic action is highly dependent the performance of PDT agents.
Therefore, PDT agents with unique photophysical properties are required in
clinical applications. There are several photosensitizers in literature and some
are available. However, most of them less than ideal due to limitations such as
low molar absorptivity and photo stabilities.
In this study, we synthesized near-IR tetrastyryl-Bodipy derivatives as
photosensitizers. These sensitizers have strong absorption in therapeutic region
and are good photo-generator of singlet oxygen. They are promising for
photodynamic therapy with their favorable properties.