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dc.contributor.advisorKonu, Özlenen_US
dc.contributor.authorÜçal, Muammeren_US
dc.date.accessioned2016-01-08T18:17:41Z
dc.date.available2016-01-08T18:17:41Z
dc.date.issued2010
dc.identifier.urihttp://hdl.handle.net/11693/15377
dc.descriptionAnkara : The Department of Molecular Biology and Genetics and the Institute of Engineering and Science of Bilkent University, 2010.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2010.en_US
dc.descriptionIncludes bibliographical references leaves 71-81.en_US
dc.description.abstractNicotine, the addictive component of tobacco, shows proliferative and antiapoptotic activity in cancer cells. Levamisole, an antihelmintic, on the other hand, has been tested as an additive chemotherapeutic agent and in treatment of nephrotic syndrome. Nicotine and levamisole are both agonists of nicotinic acetylcholine receptors; effects of these two agents have not been studied in colon cancer transcriptome. In this study, nicotine and levamisole exposed SW620 colon cancer cells, at a dose of 1 μM for 7 days, were studied with respect to changes in expression using microarrays. For data analysis, a custom R-routine which makes extensive use of open source R-BioConductor Project and associated packages has been written; and it is composed of three modules: QualCont module performs quality controls supported with several visualen_US
dc.description.statementofresponsibilityÜçal, Muammeren_US
dc.format.extentxiii, 109 leaves, illustrationsen_US
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectnicotineen_US
dc.subjectlevamisoleen_US
dc.subjectSW620en_US
dc.subjectcolon canceren_US
dc.subjectcustom R routineen_US
dc.subjectautomated microarray analysisen_US
dc.subject.lccQP801.N48 U33 2010en_US
dc.subject.lcshNicotine--Metabolism.en_US
dc.subject.lcshNicotine--Physiological effects.en_US
dc.subject.lcshColon (Anatomy)--Cancer.en_US
dc.titleInvestigation of the effects of nicotine and levamisole on SW620 colon adenocarcinoma cells using a customized r-routine for automated microarray analysisen_US
dc.typeThesisen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.publisherBilkent Universityen_US
dc.description.degreeM.S.en_US


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