Show simple item record

dc.contributor.authorDemirci, S.en_US
dc.contributor.authorCelebioglu A.en_US
dc.contributor.authorAytac, Z.en_US
dc.contributor.authorUyar, Tameren_US
dc.date.accessioned2015-07-28T12:04:10Z
dc.date.available2015-07-28T12:04:10Z
dc.date.issued2014-12-02en_US
dc.identifier.issn1759-9954
dc.identifier.urihttp://hdl.handle.net/11693/12987
dc.description.abstractSmart polymers and nanofibers are potentially intriguing materials for controlled release of bioactive agents. This work describes a new class of pH responsive nanofibers for drug delivery systems with controlled release properties. Initially, poly(4-vinylbenzoic acid-co-(ar-vinylbenzyl) trimethylammonium chloride) [poly(VBA-co-VBTAC)] was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Then, ciprofloxacin was chosen as the model drug for the release study and encapsulated into pH-responsive polymeric carriers of poly(VBA-co-VBTAC) nanofibers via electrospinning. The morphology of the electrospun nanofibers was examined by scanning electron microscopy (SEM). The structural characteristics of the pH responsive nanofibers were investigated by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The release measurements of ciprofloxacin from pH responsive nanofibers were also performed by high-performance liquid chromatography (HPLC) analysis. To show the pH sensitivity of these nanofibers, the release profile of ciprofloxacin was examined under acidic, neutral and basic conditions. The results indicate that pH responsive nanofibers can serve as effective drug carriers since the release of ciprofloxacin could be controlled by changing the pH of the environment, and therefore these drug loaded pH-responsive nanofibers might have potential applications in the biomedical field. This journal is © The Royal Society of Chemistry.en_US
dc.language.isoEnglishen_US
dc.source.titlePolymer Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/C3PY01276Jen_US
dc.titlepH-responsive nanofibers with controlled drug release propertiesen_US
dc.typeArticleen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.citation.spage2050en_US
dc.citation.epage2056en_US
dc.citation.volumeNumber5en_US
dc.citation.issueNumber6en_US
dc.instituteInstitute of Materials Science and Nanotechnologyen_US
dc.identifier.doi10.1039/C3PY01276Jen_US
dc.publisherRoyal Society of Chemistryen_US
dc.contributor.bilkentauthorUyar, Tamer
buir.contributor.orcidUyar, Tamer|0000-0002-3989-4481en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record