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      Microfluidic droplet content detection using integrated capacitive sensors

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      Author(s)
      Isgor, P. K.
      Marcali, M.
      Keser, M.
      Elbuken, C.
      Date
      2015-04
      Source Title
      Sensors and Actuators B: Chemical
      Print ISSN
      0925-4005
      Publisher
      Elsevier
      Volume
      210
      Pages
      669 - 675
      Language
      English
      Type
      Article
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      Abstract
      Microfluidic capacitive sensors have been used for detection of droplets, however they have been lacking the sensitivity required for detecting the content of droplets. In this study, we developed a scalable, portable, robust and high sensitivity capacitive microdroplet content detection system using coplanar electrodes with nanometer thick silicon dioxide (SiO2) passivation layer and off-the-shelf capacitive sensors. The microfluidic chip we have designed provides easy and rapid modification of droplet content by mixing two aqueous liquids at any given ratio. The change in dielectric constant of the droplet content leads to the change in capacitive signal. The dielectric content of droplets was modified continuously while corresponding capacitance signal was measured. The resolution of the system was measured as 3 dielectric permittivity units. The results were verified using a semiconductor parameter analyzer. The application specific integrated circuit used in this work enables a portable, low-cost detection system and matches the performance of bench-top analyzers. Automated and precise measurement of dielectric content in droplets for biochemical assay monitoring is a major application of the presented system.
      Keywords
      Microdroplets
      Capacitive Sensor
      Coplanar Electrodes
      Droplet Content Sensing
      Permalink
      http://hdl.handle.net/11693/12836
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.snb.2015.01.018
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
      • Nanotechnology Research Center (NANOTAM) 1063
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