Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings
Date
2014-07Source Title
Oncolmmunology
Electronic ISSN
2162-402X
Publisher
Taylor & Francis Inc.
Volume
3
Issue
7
Pages
950166-1 - 950166-3
Language
English
Type
ArticleItem Usage Stats
128
views
views
98
downloads
downloads
Abstract
Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon alpha (IFN alpha) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity.
Keywords
Cpg OdnType I Interferon
Vaccine Adjuvant
Dendritic Cells
Oligodeoxynucleotides
Activation
Induction