Show simple item record

dc.contributor.authorArslan-Ergul, A.en_US
dc.contributor.authorAdams, M. M.en_US
dc.date.accessioned2015-07-28T12:01:45Z
dc.date.available2015-07-28T12:01:45Z
dc.date.issued2014en_US
dc.identifier.issn1471-2202
dc.identifier.urihttp://hdl.handle.net/11693/12506
dc.description.abstractBackground: Brain aging is a multi-factorial process due to both genetic and environmental factors. The zebrafish has recently become a popular model organism for examining aging and age-related diseases because as in humans they age gradually and exhibit cognitive decline. Few studies have examined the biological changes in the aging brain that may contribute to these declines and none have examined them within individuals with respect to gender. Our aim was to identify the main genetic pathways associated with zebrafish brain aging across gender. We chose males and females from specific age groups (young, 7.5-8.5 months and old, 31-36 months) based on the progression of cognitive decline in zebrafish. RNA was isolated from individual brains and subjected to microarray and qPCR analysis. Statistical analyses were performed using a two-way ANOVA and the relevant post-hoc tests. Results: Our results demonstrated that in the brains of young and old male and female zebrafish there were over 500 differentially expressed genes associated with multiple pathways but most notably were those related to neurogenesis and cell differentiation, as well as brain and nervous system development. Conclusions: The gene expression of multiple pathways is altered with age and differentially expressed in males and females. Future studies will be aimed at determining the causal relationships of age-related changes in gene expression in individual male and female brains, as well as possible interventions that counteract these alterations.en_US
dc.language.isoEnglishen_US
dc.source.titleBMC Neuroscienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1186/1471-2202-15-29en_US
dc.subjectAgingen_US
dc.subjectMicroarrayen_US
dc.subjectBrainen_US
dc.subjectGenderen_US
dc.subjectSynapseen_US
dc.subjectNeurogenesisen_US
dc.titleGene Expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphicen_US
dc.typeArticleen_US
dc.departmentDepartment of Psychologyen_US
dc.citation.spage1en_US
dc.citation.epage11en_US
dc.citation.volumeNumber15en_US
dc.citation.issueNumber29en_US
dc.identifier.doi10.1186/1471-2202-15-29en_US
dc.publisherBioMed Centralen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record