MRI-guided gene therapy

Abstract

MRI has the ability to generate high-contrast and high-resolution images, to obtain multiple diagnostic evaluations of organ function and morphology, and to provide multiple image planes with no risk of ionizing radiation. Recent efforts have focused on using MR technology to monitor gene delivery, to enhance gene transfection/transduction, and to track gene expression. This review summarizes the current status of MRIguided gene therapy. (C) 2006 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies