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      • Department of Molecular Biology and Genetics
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      Functional analysis of co-expression networks of zebrafish ace2 reveals enrichment of pathways associated with development and disease

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      Author(s)
      Keşkuş, Ayşe Gökçe
      Tombaz, Melike
      Arıcı, Burçin İrem
      Dinçaslan, Fatma Betül
      Nabi, Afshan
      Shehwana, Huma
      Konu, Özlen
      Date
      2022-02-02
      Source Title
      Genome
      Electronic ISSN
      1480-3321
      Publisher
      Canadian Science Publishing
      Volume
      65
      Issue
      2
      Pages
      57 - 74
      Language
      English
      Type
      Article
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      Abstract
      Human Angiotensin I Converting Enzyme 2 (ACE2) plays an essential role in blood pressure regulation and SARS-CoV-2 entry. ACE2 has a highly conserved, one-to-one ortholog (ace2) in zebrafish, which is an important model for human diseases. However, the zebrafish ace2 expression profile has not yet been studied during early development, between genders, across different genotypes, or in disease. Moreover, a network-based meta-analysis for the extraction of functionally enriched pathways associated with differential ace2 expression is lacking in the literature. Herein, we first identified significant development-, tissue-, genotype-, and gender-specific modulations in ace2 expression via meta-analysis of zebrafish Affymetrix transcriptomics datasets (ndatasets = 107); and the correlation analysis of ace2 meta-differential expression profile revealed distinct positively and negatively correlated local functionally enriched gene networks. Moreover, we demonstrated that ace2 expression was significantly modulated under different physiological and pathological conditions related to development, tissue, gender, diet, infection, and inflammation using additional RNA-seq datasets. Our findings implicate a novel translational role for zebrafish ace2 in organ differentiation and pathologies observed in the intestines and liver.
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      http://hdl.handle.net/11693/111937
      Published Version (Please cite this version)
      https://doi.org/10.1139/gen-2021-0033
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