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      Ondansetron/Cyclodextrin inclusion complex nanofibrous webs for potential orally fast-disintegrating antiemetic drug delivery

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      Author(s)
      Hsiung, E.
      Celebioglu, A.
      Emin Kilic, M.
      Durgun, Engin
      Date
      2022-07-25
      Source Title
      International Journal of Pharmaceutics
      Print ISSN
      0378-5173
      Electronic ISSN
      1873-3476
      Publisher
      Elsevier
      Volume
      623
      Pages
      121921-1 - 121921-12
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Ondansetron (ODS) is an effective antiemetic drug which suffers from limited solubility and bioavailability during oral administration due to first-pass metabolism. However, these limitations can be mitigated through inclusion complexation with cyclodextrins (CDs). In this study, we have reported the electrospinning of polymer-free, free-standing ODS/CD nanofibrous webs (NW), a promising approach for developing a fast-disintegrating delivery system of an antiemetic drug molecule. Highly water soluble hydroxypropyl-beta-cyclodextrins (HPβCD) were used as both complexation agent and electrospinning matrix. The computational study revealed that the 1/2 (drug/CD) stoichiometry was more favorable compared to 1/1. The ODS/HPβCD NW was obtained with higher loading efficiency (∼96 %) compared to the control sample of ODS/polyvinyl alcohol (PVA) NW (∼80 %). The amorphous distribution of ODS raised by complexation and the highly water-soluble nature of HPβCD resulted into faster and better release profile and quite faster disintegration property (∼2 s) in artificial saliva than polymeric ODS/PVA NW. Here, ODS/HPβCD NW was generated in the absence of a toxic solvent or chemical to enable the drug loading in an amorphous state. From all reasons above, ODS/HPβCD NW might be a promising alternative to the polymeric based systems for the purpose of fast-disintegrating oral drug delivery.
      Keywords
      Electrospinning
      Cyclodextrin
      Ondansetron
      Fast disintegrating
      Oral drug delivery
      Antiemetic treatment
      Permalink
      http://hdl.handle.net/11693/111691
      Published Version (Please cite this version)
      https://doi.org/10.1016/j.ijpharm.2022.121921
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