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      Macroporous Surgical Mesh from a Natural Cocoon Composite

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      Author(s)
      Chen, Y.-M.
      Zang, L.-S.
      Koc-Bilican, B.
      Bilican, Ismail
      Holland, C.
      Cansaran-Duman, D.
      Karaduman, T.
      Çolak, A.
      Bayır, Y.
      Halici, Z.
      Ozmen, S.
      Ali, A.
      Labidi, J.
      Elbuken, Caglar
      Kaya, M.
      Date
      2022-04-25
      Source Title
      ACS Sustainable Chemistry and Engineering
      Print ISSN
      2168-0485
      Volume
      10
      Issue
      18
      Pages
      5728 - 5738
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Recently, traditional polymer-based surgical meshes have drawn unwanted attention as a result of host tissue complications arising from infection, biocompatibility, and mechanical compatibility. Seeking an alternative solution, we present a hierarchically structured nanofibrous surgical mesh derived from the naturally woven cocoon of the Japanese giant silkworm, termed MothMesh. We report that it displays nontoxicity, biocompatibility, suitable mechanical properties, and porosity while showing no adverse effect in animal trials and even appears to enhance cell proliferation. Hence, we assert that the use of this natural material may provide an effective and improved alternative to existing synthetic meshes
      Keywords
      Sustainable material
      Fibroin
      Sericin
      Biocompatibility
      Surgical mesh
      Tissue engineering
      Permalink
      http://hdl.handle.net/11693/111412
      Published Version (Please cite this version)
      http://dx.doi.org/10.1021/acssuschemeng.1c06941
      Collections
      • Department of Molecular Biology and Genetics 542
      • Graduate School of Engineering and Science 5
      • Institute of Materials Science and Nanotechnology (UNAM) 2258
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