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      Rapid TAURUS for relaxation-based color magnetic particle imaging

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      Author(s)
      Aslan, M. Tunç
      Özaslan, A. Alper
      Kurt, S.
      Muslu, Y.
      Saritas, Emine Ulku
      Date
      2022-08-03
      Source Title
      IEEE Transactions on Medical Imaging
      Print ISSN
      0278-0062
      Electronic ISSN
      1558-254X
      Publisher
      Institute of Electrical and Electronics Engineers Inc.
      Volume
      41
      Issue
      12
      Pages
      3774 - 3786
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Magnetic particle imaging (MPI) is a rapidly developing medical imaging modality that exploits the non-linear response of magnetic nanoparticles (MNPs). Color MPI widens the functionality of MPI, empowering it with the capability to distinguish different MNPs and/or MNP environments. The system function approach for color MPI relies on extensive calibrations that capture the differences in the harmonic responses of the MNPs. An alternative calibration-free x-space-based method called TAURUS estimates a map of the relaxation time constant, τ , by recovering the underlying mirror symmetry in the MPI signal. However, TAURUS requires a back and forth scanning of a given region, restricting its usage to slow trajectories with constant or piecewise constant focus fields (FFs). In this work, we propose a novel technique to increase the performance of TAURUS and enable τ map estimation for rapid and multi-dimensional trajectories. The proposed technique is based on correcting the distortions on mirror symmetry induced by time-varying FFs. We demonstrate via simulations and experiments in our in-house MPI scanner that the proposed method successfully estimates high-fidelity τ maps for rapid trajectories that provide orders of magnitude reduction in scanning time (over 300 fold for simulations and over 8 fold for experiments) while preserving the calibration-free property of TAURUS.
      Keywords
      Magnetic particle imaging
      Color MPI
      Nanoparticle relaxation
      Mirror symmetry
      X-space MPI
      Rapid trajectory
      Permalink
      http://hdl.handle.net/11693/111395
      Published Version (Please cite this version)
      https://www.doi.org/10.1109/TMI.2022.3195694
      Collections
      • Department of Electrical and Electronics Engineering 4016
      • National Magnetic Resonance Research Center (UMRAM) 301
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