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      Fabrication of nanowalled catalytically self-threaded supramolecular polyrotaxane microcapsules using droplet microfluidics

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      Author(s)
      Alizadeh-Haghighi, Elnaz
      Khaligh, Aisan
      Kalantarifard, Ali
      Elbuken, Caglar
      Tuncel, Dönüs
      Date
      2022-04-11
      Source Title
      ACS Applied Polymer Materials
      Print ISSN
      26376105
      Electronic ISSN
      2637-6105
      Publisher
      American Chemical Society
      Volume
      4
      Issue
      7
      Pages
      4681 - 4688
      Language
      English
      Type
      Article
      Item Usage Stats
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      6
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      Abstract
      Micrometer-scale monodisperse droplets are produced to generate nanowalled supramolecular microcapsules using microfluidics for high reproducibility and high-throughput manipulation, efficient material consumption, and control over hierarchical structure, shape, and size. In this study, an optimized microfluidic droplet generation technique and a unique liquid-liquid interfacial polymerization method were applied to fabricate the monodisperse polyrotaxane-based supramolecular microcapsules in a fast and simple way. To minimize the uncertainty due to droplet volume variation, the inlet pressures were supplied from the same source while lowering the interfacial tension and the main channel hydrodynamic resistance, which are critical for high monodispersity. The target polyrotaxane network (PN) was simply formed at the interface of the water and oil phases in ultra-monodisperse microdroplets via the cucurbit[6]uril (CB6)-catalyzed azide-alkyne cycloaddition (CB6-AAC) reaction between azido- and alkyne-functionalized tetraphenylporphyrin monomers (TPP-4AZ and TPP-4AL). The thickness of the interfacially assembled PN microcapsules was 20 nm as analyzed by cross-sectional TEM and TEM-EDX techniques. The resultant water-in-oil PN microcapsules were highly monodisperse in size and able to retain target molecules. Here, rhodamine 6G (Rh6G)-loaded PN microcapsules were fabricated, and the release rate of the Rh6G cargo was investigated over time for controlled drug release applications.
      Keywords
      Microfluidics
      Nanowalled microcapsules
      Monodispersity
      Supramolecules
      2D polyrotaxane network
      Interfacial polymerization
      Drug release
      Permalink
      http://hdl.handle.net/11693/111235
      Published Version (Please cite this version)
      https://dx.doi.org/10.1021/acsapm.2c00195
      Collections
      • Department of Chemistry 707
      • Institute of Materials Science and Nanotechnology (UNAM) 2256
      • Nanotechnology Research Center (NANOTAM) 1179
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