This study aims to analyze the effects of auditory and visual perception in a hospital environment to provide comfort for the outpatients. The research focused on the waiting area of an oncology polyclinic. The binaural audio recordings and 360° photographs were taken from three different locations (reception area, courtyard area, and corridor) on the site. Audio recordings were visualized through signal processing, and the photographs were evaluated through image analysis via MATLAB to show the auditory and visual differences among the locations. These three locations differed from each other in their auditory and visual environments. Regarding the hospital auditory environment, sound sources are human activity-related and technology-based. The reception area has an indoor opening, the courtyard area has indoor and outdoor openings, and the corridor area has none. Voluntary oncology outpatients in three locations in the polyclinic were given questionnaires (n=66) and interviewed (n=20). Questionnaires were analyzed in IBM SPSS Statistics, and interviews were analyzed with the Grounded Theory method in ATLAS.ti software. Equivalent Continuous A-Weighted Sound Level (LAeq) measurements were taken within the interview hours and at one-hour intervals from three locations. The questionnaire revealed that the courtyard area is calmer and more pleasant than the other areas. The conceptual framework created with semi-structured interviews showed how the auditory and visual environments affect the outpatients' perception. The conceptual framework revealed audio-visual perceptions in the hospital environment with the existing condition and outpatients' preferences and proposed suggestions for a hospital environment.