Browsing by Subject "MRI safety"
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Item Open Access Analysis of current induction on thin conductors inside the body during MRI scan(Bilkent University, 2014) Açıkel, VolkanThe aim of this thesis is to develop a method to analyze currents on thin conductor structures inside the body during Magnetic Resonance Imaging (MRI) scan based on Modified Transmission Line Method (MoTLiM). In this thesis, first, Active Implantable Medical Devices (AIMDs) are modeled and the tissue heating problem, which is a result of coupling between AIMD and incident Radio Frequency (RF) fields, is examined. Then, usage of MoTLiM to analyze the currents on the guidewires is shown by solving currents on guidewire when a toroidal transmit receive coil is used with guidewire. At first, a method to measure MoTLiM parameters of leads using a network analyzer is shown. Then, IPG case and electrode are modeled with a voltage source and impedance. Values of these parameters are found using the Modi- fied Transmission Line Method (MoTLiM) and the Methods of Moments (MoM) simulations. Once the parameter values of an electrode/IPG case model are determined, they can be connected to any lead, and tip heating can be analyzed. To validate these models, both MoM simulations and MR experiments are used. The induced currents on the leads with the IPG case or electrode connections are solved using the proposed models and MoTLiM. These results are compared with the MoM simulations. In addition, an electrode is connected to a lead via an inductor. The dissipated power on the electrode is calculated using MoTLiM by changing the inductance and the results are compared with the specific absorption rate results that are obtained using MoM. Then, MRI experiments are conducted to test the IPG case and the electrode models. To test the IPG case, a bare lead is connected to the case and placed inside a uniform phantom. During a MRI scan the temperature rise at the lead is measured by changing the lead length. The power at the lead tip for the same scenario is also calculated using the IPG case model and MoTLiM. Then an electrode is connected to a lead via an inductor and placed inside a uniform phantom. During a MRI scan the temperature rise at the electrode is measured by changing the inductance and compared with the dissipated power on the electrode resistance. Second, based on the similarity between currents on guidewires and transmission lines, currents on the catheter are solved with MoTLiM. Current distributions on an insulated guidewire are solved and B1 distribution along the catheter is calculated. Effect of stripping the tip on the tip visibility is analyzed. It is shown that there is an increase in the B1 at the insulation and bare guidewire boundary. Then, a characteristic impedance is defined for the guidewires and impedance seen at the point where guidewire is inserted into the body is calculated. It is shown with EM simulations that if the impedance converges to the characteristic impedance of the guidewire, tip visibility of the guidewire is lost. At last, a new method to measure electrical properties of a phantom material is proposed. This method is used for validation of the coaxial transmission line measurement (CTLM) fixture, which is designed for measurement of electrical properties of viscous phantom materials at MRI frequencies, and which is previously presented by our group. The new method depends on the phenomena of the lead tip heating inside a phantom during MRI scan. Electrical properties of a phantom are influential on the relationship between tip temperature increase and the lead length. MoTLiM is used and the relationship between the lead length and the tip temperature increase is formulated as a function of conductivity and permittivity of the phantom. By changing the lead length, the tip temperature increase is measured and the MoTLiM formulation is fitted to these data to find the electrical properties of the phantom. Afterwards the electrical properties of the phantom are measured with the CTLM fixture and the results that are obtained with both methods are compared for an error analysis. To sum, electrical models for the IPG case and electrode are suggested, and the method is proposed to determine the parameter values. The effect of the IPG case and electrode on tip heating can be predicted using the proposed theory. An analytical analysis of guidewire with toroidal transceiver is shown. This analysis is helpful for better usage and improvements of toroidal transceiver. Also, MoTLiM analysis can be extended to other MRI guidewire antennas.Item Open Access Measuring local RF heating in MRI: Simulating perfusion in a perfusionless phantom(John Wiley & Sons, Inc., 2007) Akca, I. B.; Ferhanoglu, O.; Yeung, C. J.; Guney, S.; Tasci, T. O.; Atalar, ErginPurpose: To overcome conflicting methods of local RF heating measurements by proposing a simple technique for predicting in vivo temperature rise by using a gel phantom experiment. Materials and Methods: In vivo temperature measurements are difficult to conduct reproducibly; fluid phantoms introduce convection, and gel phantom lacks perfusion. In the proposed method the local temperature rise is measured in a gel phantom at a timepoint that the phantom temperature would be equal to the perfused body steady-state temperature value. The idea comes from the fact that the steady-state temperature rise in a perfused body is smaller than the steady-state temperature increase in a perfusionless phantom. Therefore, when measuring the temperature on a phantom there will be the timepoint that corresponds to the perfusion time constant of the body part. Results: The proposed method was tested with several phantom and in vivo experiments. Instead, an overall average of 30.8% error can be given as the amount of underestimation with the proposed method. This error is within the variability of in vivo experiments (45%). Conclusion: With the aid of this reliable temperature rise prediction the amount of power delivered by the scanner can be controlled, enabling safe MRI examinations of patients with implants. © 2007 Wiley-Liss, Inc.Item Open Access Reconfigurable MRI technology for low-SAR imaging of deep brain stimulation at 3T: application in bilateral leads, fully-implanted systems, and surgically modified lead trajectories(Elsevier, 2019) Kazemivalipour, Ehsan; Keil, B.; Vali, A.; Rajan, S.; Elahi, B.; Atalar, Ergin; Wald, L.; Rosenow, J.; Pilitsis, J.; Golestanirad, L.Patients with deep brain stimulation devices highly benefit from postoperative MRI exams, however MRI is not readily accessible to these patients due to safety risks associated with RF heating of the implants. Recently we introduced a patient-adjustable reconfigurable coil technology that substantially reduced local SAR at tips of single isolated DBS leads during MRI at 1.5 T in 9 realistic patient models. This contribution extends our work to higher fields by demonstrating the feasibility of scaling the technology to 3T and assessing its performance in patients with bilateral leads as well as fully implanted systems. We developed patient-derived models of bilateral DBS leads and fully implanted DBS systems from postoperative CT images of 13 patients and performed finite element simulations to calculate SAR amplification at electrode contacts during MRI with a reconfigurable rotating coil at 3T. Compared to a conventional quadrature body coil, the reconfigurable coil system reduced the SAR on average by 83% for unilateral leads and by 59% for bilateral leads. A simple surgical modification in trajectory of implanted leads was demonstrated to increase the SAR reduction efficiency of the rotating coil to >90% in a patient with a fully implanted bilateral DBS system. Thermal analysis of temperature-rise around electrode contacts during typical brain exams showed a 15-fold heating reduction using the rotating coil, generating <1C temperature rise during ∼4-min imaging with high-SAR sequences where a conventional CP coil generated >10C temperature rise in the tissue for the same flip angle.Item Open Access RF heating of deep brain stimulation implants in open-bore vertical MRI systems: a simulation study with realistic device configurations(International Society for Magnetic Resonance in Medicine, 2020) Golestanirad, L.; Kazemivalipour, Ehsan; Lampman, D.; Habara, H.; Atalar, Ergin; Rosenow, J.; Pilitsis, J.; Kirsch, J.Purpose Patients with deep brain stimulation (DBS) implants benefit highly from MRI, however, access to MRI is restricted for these patients because of safety hazards associated with RF heating of the implant. To date, all MRI studies on RF heating of medical implants have been performed in horizontal closed‐bore systems. Vertical MRI scanners have a fundamentally different distribution of electric and magnetic fields and are now available at 1.2T, capable of high‐resolution structural and functional MRI. This work presents the first simulation study of RF heating of DBS implants in high‐field vertical scanners. Methods We performed finite element electromagnetic simulations to calculate specific absorption rate (SAR) at tips of DBS leads during MRI in a commercially available 1.2T vertical coil compared to a 1.5T horizontal scanner. Both isolated leads and fully implanted systems were included. Results We found 10‐ to 30‐fold reduction in SAR implication at tips of isolated DBS leads, and up to 19‐fold SAR reduction at tips of leads in fully implanted systems in vertical coils compared to horizontal birdcage coils. Conclusions If confirmed in larger patient cohorts and verified experimentally, this result can open the door to plethora of structural and functional MRI applications to guide, interpret, and advance DBS therapy.Item Open Access Vertical open-bore MRI scanners generate significantly less radiofrequency heating around implanted leads: A study of deep brain stimulation implants in 1.2T OASIS scanners versus 1.5T horizontal systems(John Wiley & Sons, Inc., 2021-04-07) Kazemivalipour, Ehsan; Bhusal, B.; Vu, J.; Lin, S.; Nguyen, B. T.; Kirsch, J.; Nowac, E.; Pilitsis, J.; Rosenow, J.; Atalar, Ergin; Golestanirad, L.Purpose Patients with active implants such as deep brain stimulation (DBS) devices are often denied access to MRI due to safety concerns associated with the radiofrequency (RF) heating of their electrodes. The majority of studies on RF heating of conductive implants have been performed in horizontal close-bore MRI scanners. Vertical MRI scanners which have a 90° rotated transmit coil generate fundamentally different electric and magnetic field distributions, yet very little is known about RF heating of implants in this class of scanners. We performed numerical simulations as well as phantom experiments to compare RF heating of DBS implants in a 1.2T vertical scanner (OASIS, Hitachi) compared to a 1.5T horizontal scanner (Aera, Siemens). Methods Simulations were performed on 90 lead models created from post-operative CT images of patients with DBS implants. Experiments were performed with wires and commercial DBS devices implanted in an anthropomorphic phantom. Results We found significant reduction of 0.1 g-averaged specific absorption rate (30-fold, P < 1 × 10−5) and RF heating (9-fold, P < .026) in the 1.2T vertical scanner compared to the 1.5T conventional scanner. Conclusion Vertical MRI scanners appear to generate lower RF heating around DBS leads, providing potentially heightened safety or the flexibility to use sequences with higher power levels than on conventional systems.