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Mammalian target of rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases
(Elsevier Inc., 2016)
Normal aging is accompanied by cognitive impairment with subtle cellular and molecular changes in the brain, whereas, pathological brain aging manifests as severe behavioral impairments with cellular pathology. Understanding ...
Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic
(BioMed Central, 2014)
Background: Brain aging is a multi-factorial process due to both genetic and environmental factors. The zebrafish
has recently become a popular model organism for examining aging and age-related diseases because as ...
Short-term dietary restriction in old zebrafish changes cell senescence mechanisms
(Elsevier, 2016-10)
Brain aging is marked by a decline in cognitive abilities and associated with neurodegenerative disorders. Recent studies have shown, neurogenesis continues into adulthood but is known to be decreasing during advancing age ...
Novel object recognition is not affected by age despite age-related brain changes
(Scientific Research Publishing, 2013)
Age-related memory impairments show a progressive decline across lifespan. Studies have demonstrated equivocal results in biological and behavioral outcomes of aging. Thus, in the present study we examined the novel object ...
Zebrafish aging models and possible interventions
(InTechOpen Press, 2018)
Across the world, the aging population is expanding due to an increasing average life expectancy. The percentage of elderly over the age of 65 is expected to be more than 15% of the total world population by 2025. As the ...
Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio)
(Elsevier, 2017-06)
The zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The ...
Expression levels of SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) and its interacting partners show region-specific alterations during brain aging
(Elsevier, 2020)
Aging occurs due to a combination of several factors, such as telomere attrition, cellular senescence, and stem cell exhaustion. The telomere attrition-dependent cellular senescence is regulated by increased levels of SMAD ...
Dietary and pharmacological interventions that inhibit mammalian target of rapamycin activity alter the brain expression levels of neurogenic and glial markers in an age-and treatment-dependent manner
(Mary Ann Liebert, 2020)
Intermittent fasting (IF) and its mimetic, rapamycin extend lifespan and healthspan through mechanisms that are not fully understood. We investigated different short-term durations of IF and rapamycin on cellular and ...
Zebrafish-A model organism for studying the neurobiological mechanisms underlying cognitive brain aging and use of potential interventions
(Frontiers Media S.A., 2018)
Classically, the zebrafish model organism has been used to elucidate the genetic and cellular mechanisms related to development since the embryo forms and grows externally following fertilization. This provides insight ...
Effects of caloric restriction on the antagonistic and integrative hallmarks of aging
(Elsevier, 2021)
Aging is a significant risk factor for cognitive decline associated with neurodegenerative diseases, which makes understanding what promotes ‘healthy brain aging’ very important. Studies suggest that caloric restriction ...