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dc.contributor.advisorAkkaya, Engin Umut
dc.contributor.authorUçar, Esma
dc.date.accessioned2019-01-15T05:36:49Z
dc.date.available2019-01-15T05:36:49Z
dc.date.copyright2018-12
dc.date.issued2019-01
dc.date.submitted2019-01-14
dc.identifier.urihttp://hdl.handle.net/11693/48244
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Chemistry, İhsan Doğramacı Bilkent University, 2018.en_US
dc.descriptionIncludes bibliographical references. (leaves 85-102).en_US
dc.description.abstractPhotodynamic therapy of cancer plays a pivotal role due to its many superior features and potential. Considering the pathways for improving the practice of PDT of cancer is gradually increasing, enhancing the selectivity of photodynamic action is an obvious choice. Being the source of reactive oxygen species in the body, mitochondrion is one of the most proper organelles to target. There is plethora of findings suggesting that triphenlyphosphonium cation is a very favorable mitochondria targeting agent. Another aspect of PDT requires creation of smart molecules which respond to either the increased temperature or ion concentrations in order to release 1O2. Cyclic endoperoxides of naphthalene and anthracene could help in achieving the desired objective of storing 1O2 and regenerating it again when appropriate conditions meet. The half-life cycloreversion of 1,4-Dimethylnaphthalene could be changed at least 100-fold when 2-position of the naphthalene is sterically hindered. Taking advantage of the fact that fluoride ions’ silicophile nature, a novel perspective for drug design can be proposed. In the final project, a certain level magnetic hyperthermia, large enough to cause endoperoxide cycloreversion, but not large enough to cause necrotic death, is being sought after. Controlled generation singlet oxygen by the application of tissue penetrating alternating magnetic fields is the ultimate goal for that project.en_US
dc.description.statementofresponsibilityby Esma Uçar.en_US
dc.format.extentxvi, 129 leaves : illustrations, charts ; 30 cm.en_US
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPDTen_US
dc.subjectMitochondriaen_US
dc.subjectMagnetic Fluid Hyperthermiaen_US
dc.subjectEndoperoxideen_US
dc.titleTargeted photosensitizers and controlled singlet oxygen generation for therapeutic applicationsen_US
dc.title.alternativeTerapötik uygulamalar için hedeflenmiş fotoduyarlaştırıcılar ve kontrollü sınglet oksijen üretimien_US
dc.typeThesisen_US
dc.departmentDepartment of Chemistryen_US
dc.publisherBilkent Universityen_US
dc.description.degreeM.S.en_US
dc.identifier.itemidB159518
dc.embargo.release2019-07-14


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