LoC sensor array platform for real-time coagulation measurements
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Institute of Electrical and Electronics Engineers Inc.
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/27870
This paper reports a MEMS-based sensor array enabling multiple clot-time tests in one disposable microfluidic cartridge using plasma. The versatile LoC (Lab-on-Chip) platform technology is demonstrated here for real-time coagulation tests (activated Partial Thrompoblastin Time (aPTT) and Prothrombin Time (PT)). The system has a reader unit and a disposable cartridge. The reader has no electrical connections to the cartridge, which consists of multiple microfluidic channels and MEMS microcantilevers placed in each channel. Microcantilevers are made of electro-plated nickel and actuated remotely using an external electro-coil. The read-out is also conducted remotely by a laser and the phase of the MEMS oscillator is monitored real-time. The system is capable of monitoring coagulation time with a precision estimated at 0.1sec. © 2014 IEEE.
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