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      Implantable microelectromechanical sensors for diagnostic monitoring and post-surgical prediction of bone fracture healing

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      Author
      McGilvray, K. C.
      Ünal, E.
      Troyer, K. L.
      Santoni, B. G.
      Palmer, R. H.
      Easley, J. T.
      Demir, Hilmi Volkan
      Puttlitz, C. M.
      Date
      2015
      Source Title
      Journal of Orthopaedic Research
      Print ISSN
      0736-0266
      Publisher
      John Wiley and Sons Inc.
      Volume
      33
      Issue
      10
      Pages
      1439 - 1446
      Language
      English
      Type
      Article
      Item Usage Stats
      137
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      159
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      Abstract
      The relationship between modern clinical diagnostic data, such as from radiographs or computed tomography, and the temporal biomechanical integrity of bone fracture healing has not been well-established. A diagnostic tool that could quantitatively describe the biomechanical stability of the fracture site in order to predict the course of healing would represent a paradigm shift in the way fracture healing is evaluated. This paper describes the development and evaluation of a wireless, biocompatible, implantable, microelectromechanical system (bioMEMS) sensor, and its implementation in a large animal (ovine) model, that utilized both normal and delayed healing variants. The in vivo data indicated that the bioMEMS sensor was capable of detecting statistically significant differences (p-value <0.04) between the two fracture healing groups as early as 21 days post-fracture. In addition, post-sacrifice micro-computed tomography, and histology data demonstrated that the two model variants represented significantly different fracture healing outcomes, providing explicit supporting evidence that the sensor has the ability to predict differential healing cascades. These data verify that the bioMEMS sensor can be used as a diagnostic tool for detecting the in vivo course of fracture healing in the acute post-treatment period. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
      Keywords
      Implanted
      Biomechanics
      Histology
      Micro computed tomography
      Microelectromechanical system (MEMS)
      Animal experiment
      Animal model
      Animal tissue
      Biocompatibility
      Biosensor
      Controlled study
      Diagnosis
      Fracture healing
      Histopathology
      In vivo study
      Micro - computed tomography
      Microelectromechanical system
      Molecular sensor
      Nonhuman
      Priority journal
      Sheep
      Statistical significance
      Wound healing impairment
      Ambulatory monitoring
      Devices
      Electrode implant
      Evaluation study
      Materials testing
      Animals
      Electrodes
      Materials testing
      Micro - electrical - mechanical systems
      Monitoring
      Telemetry
      Permalink
      http://hdl.handle.net/11693/20815
      Published Version (Please cite this version)
      http://dx.doi.org/10.1002/jor.22918
      Collections
      • Department of Electrical and Electronics Engineering 3524
      • Department of Physics 2299
      • Institute of Materials Science and Nanotechnology (UNAM) 1775
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