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Now showing items 161-167 of 167
Cloning and expression profile of FLT3 gene during rat liver regeneration
(Bilkent University, 2005)
Liver has a unique capacity to regenerate itself upon exposure to viral infections,
toxic reactions and cancer formation which result in the loss of hepatocyte. Liver
regeneration is a complex phenomenon in which several ...
Role of the nuclear matrix protein C1D in regulation of transcription
(Bilkent University, 2001)
The nuclear matrix protein C1D is an activator of DNA-dependent protein kinase (DNAPK),
which is involved in non-homologous end joining and V(D)J recombination. Moreover, the
nuclear matrix proteins C1D was shown to be ...
Identification of genes involved in hepatocellular carcinoma : evaluation of hCdc4 and B-Raf genes
(Bilkent University, 2003)
Hepatocellular carcinoma (HCC), the major type of primary liver cancer, is one of the
most common cancers worldwide. Development and progression of HCC occur as a
multistep process, requiring the activation of oncogenes ...
The expression of BCL-2 family of genes during liver regeneration
(Bilkent University, 2001)
Hepatic regeneration is a process that includes cellular proliferation and cellular
death. Apoptosis is the main tool for the organism to control the death in order to
prevent the destruction of the tissues, and maintain ...
Identification of RNA-based biomarkers associated with manic episodes and lithium response in bipolar disorder
(Bilkent University, 2022-12)
Bipolar disorder (BD) is one of the major mood disorders. A person afflicted with this neuropsychiatric disease undergoes episodes of depression and mania. BD ranks as the highest amongst all the mood disorders for having ...
Identification and targeting of deregulated metabolic pathways in metastatic prostate cancer cells
(Bilkent University, 2023-01)
Prostate cancer is the most diagnosed cancer type and the second leading cause of death in men globally. The pathogenesis of prostate cancer mainly relies on the androgen signaling axis. Therefore, androgen deprivation ...
Detection of phosphorylation signatures specific to cancer-related PI3-Kinase isoforms p110α and p110β
(Bilkent University, 2023-01)
The PI3K signaling pathway is required for many physiological activities, but it is commonly disrupted during cancer formation. The PI3K p110α and βisoforms, encoded by the PIK3CA and PIK3CB genes, are lipid kinases that ...