Now showing items 21-40 of 422

    • Potent stimulation of the innate immune system by nucleic acid based TLR ligands encapsulated in nanoliposomes 

      Bayyurt, Banu; Gürsel, İhsan (Association for Cancer Immunotherapy, 2012-05)
      Nucleic acids with bacterial and viral origins are recognized by toll like receptors (TLRs) that triggers mammalian innate immune system to secrete proinflammatory or inflammatory cytokines. Even though these ligands have ...
    • Zebrafish aging models and possible interventions 

      Birand, Dilan Ç.; Erbaba, Begün; Özdemir, Ahmet T.; Kafalıgönül, Hulusi; Adams, Michelle (InTechOpen Press, 2018)
      Across the world, the aging population is expanding due to an increasing average life expectancy. The percentage of elderly over the age of 65 is expected to be more than 15% of the total world population by 2025. As the ...
    • Suppression subtractive hybridization technology 

      Yuluğ, Işık; Atalay, A. (Elsevier, 2004)
      This chapter describes suppression subtractive hybridization (SSH)—a sophisticated cDNA subtraction method to enrich and isolate differentially expressed genes. SSH accomplishes normalization and subtraction by taking ...
    • Inflammatory causes of obesity and metabolic diseases 

      Erbay, Ebru; Hotamışlıgil, G. S. (CRC Press, 2014)
    • Development of CpG ODN based vaccine adjuvant formulations 

      Gürsel, M.; Gürsel, İhsan (Humana Press, New York, 2016)
    • TP53 and hepatocellular carcinoma 

      Puisieux, A.; Ozturk, M. (Elsevier Masson, 1997)
    • Oncogenic kinase-induced PKM2 tyrosine 105 phosphorylation converts nononcogenic PKM2 to a tumor promoter and induces cancer stem-like cells 

      Zhou, Z.; Li, M.; Zhang, L.; Zhao, H.; Sahin, Ö.; Chen, J.; Zhao, J. J.; Songyang, Z.; Yu, D. (American Association for Cancer Research, 2018)
      The role of pyruvate kinase M2 isoform (PKM2) in tumor progression has been controversial. Previous studies showed that PKM2 promoted tumor growth in xenograft models; however, depletion of PKM2 in the Brca1-loss–driven ...
    • Early detection and staging of colorectal cancer using a panel of micro RNAs 

      Shapira, R.; Ilyayev, N.; Attali, R.; Westrich, G.; Halle, D.; Speter, C.; Stavropoulos, A. V.; Roistacher, M.; Pavlov, V.; Grinbaum, R.; Protic, P.; Gure, A. O.; Bilchik, A. J.; Stojadinovic, A.; Mitrani-Rosenbaum, S.; Nissan, A. (OMICS, 2018)
      Purpose: To improve lymph node (LN) staging in patients with colon cancer (CC). The present study describes the selection of CC-specific miRNAs and assesses their utility as a micro metastases detection assay. Methods: ...
    • Abnormal subcortical activity in congenital mirror movement disorder with RAD51 mutation 

      Demirayak, Pınar; Onat, Onur Emre; Gevrekci, A. Ö.; Gülsüner, S.; Uysal, H.; Bilgen, R.; Doerschner, Katja.; Özçelik, Tayfun; Boyacı, Hüseyin (Turkish Society of Radiology, 2018)
      PURPOSE Congenital mirror movement disorder (CMMD) is characterized by unintended, nonsuppressible, homologous mirroring activity contralateral to the movement on the intended side of the body. In healthy controls, unilateral ...
    • IKBKE inhibits TSC1 to activate the mTOR/S6K pathway for oncogenic transformation 

      Göktuna, S. İ. (Scientific and Technical Research Council of Turkey - TUBITAK,Turkiye Bilimsel ve Teknik Arastirma Kurumu, 2018)
      IKBKE (IKKε) has emerged as a key modulator of multiple substrates, controlling oncogenic pathways in various malignancies. mTOR signaling, required for cellular growth, proliferation, and vascular angiogenesis in cancer, ...
    • SIK2 attenuates proliferation and survival of breast cancer cells with simultaneous perturbation of MAPK and PI3K/Akt pathways 

      Zohrap, N.; Saatci, Ö.; Ozes, B.; Coban, I.; Atay, H. M.; Battaloglu, E.; Şahin, Ö.; Bugra, K. (Impact Journals LLC, 2018)
      Salt Inducible Kinase2 (SIK2) has been shown to contribute to tumorigenesis in multiple tumor types in a dichotomous manner. However, little is known about its contribution to breast malignancies. Here, we report SIK2 as ...
    • Cholinergic receptor nicotinic alpha 5 (CHRNA5) RNAi is associated with cell cycle inhibition, apoptosis, DNA damage response and drug sensitivity in Breast cancer 

      Koker, Sahika Cingir; Jahja, Ermira; Shehwana, Huma; Keskus, Ayse Gokce; Konu, Ozlen (Public Library of Science, 2018)
      Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is an important susceptibility locus for nicotine addiction and lung cancer. Depletion of CHRNA5 has been associated with reduced cell viability, increased apoptosis and ...
    • Discovering lncRNA mediated sponge interactions in breast cancer molecular subtypes 

      Olgun, G.; Sahin, O.; Tastan, O. (BioMed Central, 2018)
      Background: Long non-coding RNAs (lncRNAs) can indirectly regulate mRNAs expression levels by sequestering microRNAs (miRNAs), and act as competing endogenous RNAs (ceRNAs) or as sponges. Previous studies identified ...
    • A case report of syndromic multinodular goitre in adolescence: Exploring the phenotype overlap between cowden and DICER1 syndromes 

      Soglio, D. B.; Kock, L.; Gauci, R.; Sabbaghian, N.; Thomas, E.; Atkinson, H. C.; Pachter, N.; Ryan, S.; Walsh, J. P.; Kumarasinghe, M. P.; Carpenter, K.; Aydoğan, A.; Stewart, C. J. R.; Foulkes, W. D.; Choong, C. S. (S. Karger AG, 2018)
      Background: Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic ...
    • Polyol pathway links glucose metabolism to the aggressiveness of cancer cells 

      Schwab, A.; Siddiqui, A.; Vazakidou, M. E.; Napoli, F.; Bottcher, M.; Menchicchi, B.; Raza, U.; Saatci, O.; Krebs, A. M.; Ferrazzi, F.; Rapa, I.; Wilde, K. D.; Waldner, M. J.; Ekici, A. B.; Rasheed, S. A. K.; Mougiakakos, D.; Oefner, P. J.; Sahin, O.; Volante, M.; Greten, F. R.; Brabletz, T.; Ceppi, P. (American Association for Cancer Research, 2018)
      Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with ...
    • Tuberculosis and impaired IL-23-dependent IFN-γ immunity in humans homozygous for a common TYK2 missense variant 

      Boisson-Dupuis, S.; Ramirez-Alejo, N.; Li, Z.; Patin, E.; Rao, G.; Kerner, G.; Lim, C. K.; Krementsov, D. N.; Hernandez, N.; Ma, C. S.; Zhang, Q.; Markle, J.; Martinez-Barricarte, R.; Payne, K.; Fisch, R.; Deswarte, C.; Halpern, J.; Bouaziz, M.; Mulwa, J.; Sivanesan, D.; Lazarov, T.; Naves, R.; Garcia, P.; Itan, Y.; Boisson, B.; Checchi, A.; Jabot-Hanin, F.; Cobat, A.; Guennoun, A.; Jackson, C. C.; Pekcan, S.; Caliskaner, Z.; Inostroza, J.; Costa-Carvalho, B. T.; de, Albuquerque, J. A. T.; Garcia-Ortiz, H.; Orozco, L.; Ozcelik, T.; Abid, A.; Rhorfi, I. A.; Souhi, H.; Amrani, H. N.; Zegmout, A.; Geissmann, F.; Michnick, S. W.; Muller-Fleckenstein, I.; Fleckenstein, B.; Puel, A.; Ciancanelli, M. J.; Marr, N.; Abolhassani, H.; Balcells, M. E.; Condino-Neto, A.; Strickler, A.; Abarca, K.; Teuscher, C.; Ochs, H. D.; Reisli, I.; Sayar, E. H.; El-Baghdadi, J.; Bustamante, J.; Hammarström, L.; Tangye, S. G.; Pellegrini, S.; Quintana-Murci, L.; Abel, L.; Casanova, J. -L. (NLM (Medline), 2018)
      Inherited IL-12Rβ1 and TYK2 deficiencies impair both IL-12- and IL-23-dependent IFN-γ immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 individuals. We show that homozygosity for the ...
    • IKKs and tumor cell plasticity 

      Göktuna, S. I.; Diamanti, M. A.; Chau, T. L. (Wiley-Blackwell Publishing Ltd., 2018)
      Nuclear factor κB (NF-κB) transcription factors are the central hubs of signaling pathways connecting proinflammatory signals to cell survival, proliferation and cytokine production. In cancers, NF-κB signaling influences ...
    • Modules of correlated genes in a gene expression regulatory network of CDDP-resistant cancer cells 

      Vargas, D. J.; Acón, M. S.; Sahin, Özgür; Eyüpoğlu, Erol; Riazalhosseini, Y.; Mora, J. M.; Coto, J. G.; Rodriguez, R. M. (Institute of Electrical and Electronics Engineers, 2018)
      Chemotherapeutic drugs have been used as important strategies in cancer treatment. However, chemotherapy-resistant tumors arise especially in relapsing and progressive disease. Understanding of mechanisms underlaying ...
    • Heterodoped manoparticles as dual-mode contrast agent for MRI 

      Alipour, Akbar; Sharma, Vijay Kumar; Soran-Erdem, Zeliha; Kelestemur, Yusuf; Aykut, Zaliha Gamze; Demir, Hilmi Volkan (IEEE, 2018)
      The purpose of this work is to synthesize Mn-Fe heterodoped ZnSe tetrapod nanocrystals (NCs) as dualmode MRI contrast agent to offer synergetic beneficial over the single contrast tracer. Also, in vivo feasibility of the ...
    • Contrast enhancement of microscopy images using image phase information 

      Cakir, S.; Kahraman, D. C.; Cetin Atalay, R.; Çetin, A. Enis (Institute of Electrical and Electronics Engineers, 2018)
      Contrast enhancement is an important preprocessing step for the analysis of microscopy images. The main aim of contrast enhancement techniques is to increase the visibility of the cell structures and organelles by modifying ...