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A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains
(John Wiley & Sons, Inc., 2018)
This large multi‐center study investigates the relationships between genetic risk for schizophrenia and bipolar disorder, and multi‐modal endophenotypes for psychosis. The sample included 4,242 individuals; 1,087 patients ...
The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: a collaborative cognitive and neuroimaging genetics project
(Elsevier B.V., 2018--05)
Background: Schizophrenia has a large genetic component, and the pathways from genes to illness manifestation are beginning to be identified. The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia ...
Polygenic risk score increases schizophrenia liability through cognition-relevant pathways
(Oxford University Press, 2019-02)
Cognitive deficit is thought to represent, at least in part, genetic mechanisms of risk for schizophrenia, with recent evidence from statistical modelling of twin data suggesting direct causality from the former to the ...