Now showing items 1-8 of 8

    • Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio) 

      Karoglu, E. T.; Halim, D. O.; Erkaya, B.; Altaytas, F.; Arslan-Ergul, A.; Konu, O.; Adams, M. M. (Elsevier, 2017-06)
      The zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The ...
    • Aging, neurogenesis, and caloric restriction in different model organisms 

      Ergul, A. A.; Ozdemir A.T.; Adams, M. M. (International Society on Aging and Disease, 2013)
      Brain aging is a multifactorial process that is occurring across multiple cognitive domains. A significant complaint that occurs in the elderly is a decrement in learning and memory ability. Both rodents and zebrafish ...
    • Homozygosity mapping and targeted genomic sequencing reveal the game responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred 

      Gulsuner, S.; Tekinay, A. B.; Doerschner, K.; Boyaci, H.; Bilguvar, K.; Unal, H.; Ors, A.; Onat, O. E.; Atalar, E.; Basak, A. N.; Topaloglu, H.; Kansu, T.; Tan, M.; Tan, U.; Gunel, M.; Ozcelik, T. (Cold Spring Harbor Laboratory Press, 2011-09-01)
      The biological basis for the development of the cerebro-cerebellar structures required for posture and gait in humans is poorly understood. We investigated a large consanguineous family from Turkey exhibiting an extremely ...
    • Identification of a novel missense mutation in RAD51 in a large family with congenital mirror movements 

      Onat, Onur Emre; Gülsüner, Süleyman; Bilgen, R.; Dal, G. M.; Bilguvar, K.; Boyacı, Hüseyin; Doerschner, Katja; Uysal, H.; Günel, M.; Özçelik, Tayfun (American Society of Human Genetics, 2012-11)
      Congenital mirror movements (CMM) are a rare and heterogeneous group of disorders characterized by involuntary contralateral movements of mainly the upper extremities during intentional movements on the opposite side. ...
    • Mammalian target of rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases 

      Celebi-Birand, Ergül Dilan; Karoğlu, Elif Tuğçe; Doldur-Ballı, Füsun; Adams, Michelle M. (Elsevier Inc., 2016)
      Normal aging is accompanied by cognitive impairment with subtle cellular and molecular changes in the brain, whereas, pathological brain aging manifests as severe behavioral impairments with cellular pathology. Understanding ...
    • Short-term dietary restriction in old zebrafish changes cell senescence mechanisms 

      Arslan-Ergul, A.; Erbaba, B.; Karoglu, E. T.; Halim, D. O.; Adams, M. M. (Elsevier, 2016-10)
      Brain aging is marked by a decline in cognitive abilities and associated with neurodegenerative disorders. Recent studies have shown, neurogenesis continues into adulthood but is known to be decreasing during advancing age ...
    • Systematic discovery of Rab GTPases with synaptic functions in Drosophila 

      Chan, C.-C.; Scoggin, S.; Wang, D.; Cherry, S.; Dembo, T.; Greenberg, B.; Jin, E.J.; Kuey, C.; Lopez, A.; Mehta, S.Q.; Perkins, T.J.; Brankatschk, M.; Rothenfluh, A.; Buszczak, M.; Hiesinger P.R. (2011)
      Background: Neurons require highly specialized intracellular membrane trafficking, especially at synapses. Rab GTPases are considered master regulators of membrane trafficking in all cells, and only very few Rabs have known ...
    • Zebrafish aging models and possible interventions 

      Birand, Dilan Ç.; Erbaba, Begün; Özdemir, Ahmet T.; Kafalıgönül, Hulusi; Adams, Michelle (InTechOpen Press, 2018)
      Across the world, the aging population is expanding due to an increasing average life expectancy. The percentage of elderly over the age of 65 is expected to be more than 15% of the total world population by 2025. As the ...