Design and fabrication of a microfluidic device for synthesis of chitosan nanoparticles
Asik, M. D.
Journal of Nanotechnology in Engineering and Medicine
1949-2944 (Print)1949-2952 (Online)
031004-1 - 031004-6
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Cetin, B., Asik, M. D., & Taze, S. (2013). Design and fabrication of a microfluidic device for synthesis of chitosan nanoparticles. Journal of Nanotechnology in Engineering and Medicine, 4(3), 031004.
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/11864
Chitosan nanoparticles have a biodegradable, biocompatible, nontoxic structure, and are commonly used for drug delivery systems. In this study, design, modeling, and fabrication methodology of a microfluidic device for the synthesis of chitosan nanoparticles is presented. In the modeling, 2D flow and concentration field is computed using COMSOL Multiphysics® simulation environment to predict the performance of the device. The microfluidic chip is fabricated out of PDMS. The fabrication of the mold for the microfluidic device is performed using high-precision micromachining. Some preliminary proof-of-concept experiments were performed. It was observed that compared to conventional batch-type methods, the proposed microfluidic device can perform the synthesis much faster and in a much automated and convenient manner. Copyright © 2013 by ASME.