Expression of IFITM1 in chronic myeloid leukemia patients
Akyerli, C. B.
Williams, B. R. G.
Akyerli, C. B., Beksac, M., Holko, M., Frevel, M., Dalva, K., Özbek, U., ... & Gürman, G. (2005). Expression of IFITM1 in chronic myeloid leukemia patients. Leukemia research, 29(3), 283-286.
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/11369
We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival. (C) 2004 Elsevier Ltd. All rights reserved.