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      Antibacterial nanofibers of pullulan/tetracycline-cyclodextrin inclusion complexes for fast-disintegrating oral drug delivery

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      Embargo Lift Date: 2023-12-08
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      Author(s)
      Hsiung, E.
      Celebioglu, A.
      Chowdhury, R.
      Kilic, M. E.
      Durgun, Engin
      Altier, C.
      Uyar, T.
      Date
      2021-12-08
      Source Title
      Journal of Colloid and Interface Science
      Print ISSN
      0021-9797
      Electronic ISSN
      1095-7103
      Publisher
      Elsevier Inc.
      Volume
      610
      Pages
      321 - 333
      Language
      English
      Type
      Article
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      Abstract
      Tetracycline is a widely used antibiotic suffering from poor water solubility and low bioavailability. Here, hydroxypropyl-beta-cyclodextrin (HPβCD) was used to form inclusion complexes (IC) of tetracycline with 2:1 M ratio (CD:drug). Then, tetracycline-HPβCD-IC was mixed with pullulan- a non-toxic, water-soluble biopolymer - to form nanofibrous webs via electrospinning. The electrospinning of pullulan/tetracycline-HPβCD-IC was yielded into defect-free nanofibers collected in the form of a self-standing and flexible material with the loading capacity of ∼ 7.7 % (w/w). Pullulan/tetracycline nanofibers was also generated as control sample having the same drug loading. Tetracycline was found in the amorphous state in case of pullulan/tetracycline-HPβCD nanofibers due to inclusion complexation. Through inclusion complexation with HPβCD, enhanced aqueous solubility and faster release profile were provided for pullulan/tetracycline-HPβCD-IC nanofibers compared to pullulan/tetracycline one. Additionally, pullulan/tetracycline-HPβCD-IC nanofibers readily disintegrated when wetted with artificial saliva while pullulan/tetracycline nanofibers were not completely absorbed by the same simulate environment. Electrospun nanofibers showed promising antibacterial activity against both gram-positive and gram-negative bacteria. Briefly, our findings indicated that pullulan/tetracycline-HPβCD-IC nanofibers could be an attractive material as orally fast disintegrating drug delivery system for the desired antibiotic treatment thanks to its promising physicochemical and antibacterial properties.
      Keywords
      Cyclodextrin
      Electrospinning
      NanofibersInclusion complex
      Tetracycline
      Antibiotic
      Fast disintegrating
      Fast dissolving
      Oral drug delivery
      Antibacterial
      Permalink
      http://hdl.handle.net/11693/111222
      Published Version (Please cite this version)
      https://doi.org/10.1016/j.jcis.2021.12.013
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      • Institute of Materials Science and Nanotechnology (UNAM) 2258
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