Now showing items 1-2 of 2

    • Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells 

      Küçük, C.; Jiang, B.; Hu X.; Zhang W.; Chan J.K.C.; Xiao W.; Lack, N.; Alkan, C.; Williams J.C.; Avery, K.N.; Kavak P.; Scuto, A.; Sen, E.; Gaulard P.; Staudt L.; Iqbal J.; Zhang W.; Cornish, A.; Gong Q.; Yang Q.; Sun H.; D'Amore F.; Leppä, S.; Liu W.; Fu, K.; De Leval L.; McKeithan, T.; Chan W.C. (Nature Publishing Group, 2015)
      Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell lymphomas (n=51), γδ-T-cell ...
    • The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity 

      Sag, D.; Cekic, C.; Wu, R.; Linden J.; Hedrick, C.C. (Nature Publishing Group, 2015)
      ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1-/- mice ...