Now showing items 1-8 of 8

    • A chronic myeloid leukemia-like syndrome case with del (12) (p12) in a Li-Fraumeni syndrome family 

      Guran, Ş.; Beyan, C.; Nevruz, O.; Yakıcıer, C.; Tunca, Y. (Blackwell Publishing Ltd, 2005)
      Li-Fraumeni syndrome is a familial cancer syndrome characterized by different tumors and hereditary p53 mutations. Here, a chronic myeloid leukemia-like syndrome case in a Li-Fraumeni syndrome family with del (12) (p12) ...
    • Concomitant inactivation of p53 and Chk2 in breast cancer 

      Sullivan, A.; Yuille, M.; Repellin, C.; Reddy, A.; Reelfs, O.; Bell, A.; Dunne, B.; Gusterson, B. A.; Osin, P.; Farrell, P. J.; Yulug, I.; Evans, A.; Ozcelik, T.; Gasco, M.; Crook, T. (Nature Publishing Group, 2002)
    • Genetic aspects of hepatocellular carcinogenesis 

      Ozturk, M. (1999)
      Hepatocellular carcinoma (HCC) is linked etiologically to viruses (hepatitis B virus [HBV] and hepatitis C virus [HCV]), chemical carcinogens (i.e., aflatoxins), and other environmental and host factors causing chronic ...
    • In silico analysis of mutant p53(R249S) oncogenicity in hepatocellular carcinoma 

      Ovezmuradov, Guvanchmurad (Bilkent University, 2007)
      Oncogenic properties of mutant p53 proteins still stand as an ill-known subject, and the mechanism responsible for this phenomenon remains to be uncovered. This thesis aims to uncover the effect of p53 codon R249S ...
    • A monoclonal antibody against DNA binding helix of p53 protein 

      Yolcu, E.; Sayan, B. S.; Yağci, T.; Cetin Atalay, R.; Soussi, T.; Yurdusev, N.; Ozturk, M. (Nature Publishing Group, 2001)
      Three monoclonal antibodies (Mabs) were generated against p53 DNA-binding core domain. When tested by immunoprecipitation, Western blot and immunofluorescence techniques, Mab 9E4, as well as 7D3 and 6B10 reacted with both ...
    • p53 mutation as a source of aberrant β-catenin accumulation in cancer cells 

      Cagatay, T.; Ozturk, M. (2002)
      β-catenin is involved in both cell-cell interactions and wnt pathway-dependent cell fate determination through its interactions with E-cadherin and TCF/LEF transcription factors, respectively. Cytoplasmic/nuclear levels ...
    • Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells 

      Ozturk, N.; Erdal, E.; Mumcuoglu, M.; Akcali, K. C.; Yalcin, O.; Senturk, S.; Arslan-Ergul, A.; Gur, B.; Yulug, I.; Cetin Atalay, R.; Yakicier, C.; Yagci, T.; Tez, M.; Ozturk, M. (National Academy of Sciences, 2006)
      Tumor cells have the capacity to proliferate indefinitely that is qualified as replicative immortality. This ability contrasts with the intrinsic control of the number of cell divisions in human somatic tissues by a mechanism ...
    • TP53 mutations in familial breast cancer: Functional aspects 

      Gasco, M.; Yulug, I. G.; Crook, T. (John Wiley & Sons, Inc., 2003)
      Mutation in p53 (TP53) remains one of the most commonly described genetic events in human neoplasia. The occurrence of mutations is somewhat less common in sporadic breast carcinomas than in other cancers, with an overall ...