Browsing by Keywords "mouse"
Now showing items 1-14 of 14
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Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment
(American Association for Cancer Research Inc., 2014)Adenosine A2A receptor (A2AR) blockade enhances innate and adaptive immune responses. However, mouse genetic studies have shown that A2AR deletion does not inhibit the growth of all tumor types. In the current study, we ... -
Chitosan polysaccharide suppress toll like receptor dependent immune response
(Turkish Society of Immunology, 2015)Objectives: Chitosan is a widely used vaccine or anti-cancer delivery vehicle. In this study, we investigated the immunomodulatory effect of chitosan/pIC nanocomplexes on mouse immune cells. Materials and methods: Proliferative ... -
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity
(Nature Publishing Group, 2015)ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1-/- mice ... -
Identification of novel neutralizing single-chain antibodies against vascular endothelial growth factor receptor 2
(2011)Human vascular endothelial growth factor (VEGF) and its receptor (VEGFR-2/kinase domain receptor [KDR]) play a crucial role in angiogenesis, which makes the VEGFR-2 signaling pathway a major target for therapeutic applications. ... -
In vitro biocompatibility of plasma-aided surface-modified 316L stainless steel for intracoronary stents
(Institute of Physics Publishing, 2010)316L-type stainless steel is a raw material mostly used for manufacturing metallic coronary stents. The purpose of this study was to examine the chemical, wettability, cytotoxic and haemocompatibility properties of 316L ... -
Induction of potent protection against acute and latent herpes simplex virus infection in mice vaccinated with dendritic cells
(2013)Background aims. Dendritic cells (DCs) are the most potent antigen presenting cells of the immune system and have been under intense study with regard to their use in immunotherapy against cancer and infectious disease ... -
MAb 6D5 against proteins overexpressed in hepatocellular carcinoma cell lines
(2007)[No abstract available] -
MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling
(2011)The MST1 serine - threonine kinase, a component of the RASSF1-LATS tumor suppressor network, is involved in cell proliferation and apoptosis and has been implicated in cancer. However, the physiologic role of MST1 in ... -
Myeloid expression of adenosine a2A receptor suppresses T and NK cell responses in the solid tumor microenvironment
(American Association for Cancer Research Inc., 2014)High concentrations of adenosine in tumor microenvironments inhibit antitumor cytotoxic lymphocyte responses. Although T cells express inhibitory adenosine A2A receptors (A2AR) that suppress their activation and inhibit ... -
De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder
(Elsevier, 2014)Whole-exome sequencing (WES) studies have demonstrated the contribution of de novo loss-of-function single-nucleotide variants (SNVs) to autism spectrum disorder (ASD). However, challenges in the reliable detection of de ... -
PATZ1 is a DNA damage-responsive transcription factor that inhibits p53 function
(American Society for Microbiology, 2015)Insults to cellular health cause p53 protein accumulation, and loss of p53 function leads to tumorigenesis. Thus, p53 has to be tightly controlled. Here we report that the BTB/POZ domain transcription factor PATZ1 (MAZR), ... -
Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes α7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons
(2009)Vertebrate α-bungarotoxin-like molecules of the Ly-6 superfamily have been implicated as balancers of activity and survival in the adult nervous system. To determine whether a member of this family could be involved in the ... -
A role for LYNX2 in anxiety-related behavior
(2009)Anxiety disorders are the most prevalent mental disorders in developed societies. Although roles for the prefrontal cortex, amygdala, hippocampus and mediodorsal thalamus in anxiety disorders are well documented, molecular ... -
Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine
(2008)S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a ...
