Now showing items 1-20 of 78

    • Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells 

      Küçük, C.; Jiang, B.; Hu X.; Zhang W.; Chan J.K.C.; Xiao W.; Lack, N.; Alkan, C.; Williams J.C.; Avery, K.N.; Kavak P.; Scuto, A.; Sen, E.; Gaulard P.; Staudt L.; Iqbal J.; Zhang W.; Cornish, A.; Gong Q.; Yang Q.; Sun H.; D'Amore F.; Leppä, S.; Liu W.; Fu, K.; De Leval L.; McKeithan, T.; Chan W.C. (Nature Publishing Group, 2015)
      Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell lymphomas (n=51), γδ-T-cell ...
    • Advances in plasmonic technologies for point of care applications 

      Tokel O.; Inci F.; Demirci U. (American Chemical Society, 2014)
      Infectious diseases have considerable economic and societal impact on developing settings. For instance, malaria is observed more commonly in sub-Saharan Africa and India. The societal impact of acquired immune deficiency ...
    • Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles 

      Çikla-Süzgün P.; Kaushik-Basu, N.; Basu, A.; Arora P.; Talele, T.T.; Durmaz I.; Çetin-Atalay, R.; Küçükgüzel, S.G. (Taylor and Francis Ltd, 2015)
      Arachidonic acid is an unsaturated fatty acid liberated from phospholipids of cell membranes. NSAIDs are known as targets of cyclooxygenase enzyme (COX-1, COX-2 and COX-3) in arachidonic acid metabolism. This mechanism of ...
    • Application of the Ugi reaction with multiple amino acid-derived components: Synthesis and conformational evaluation of piperazine-based minimalist peptidomimetics 

      Stucchi, M.; Cairati, S.; Cetin-Atalay, R.; Christodoulou, M.S.; Grazioso G.; Pescitelli G.; Silvani, A.; Yildirim, D.C.; Lesma G. (Royal Society of Chemistry, 2015)
      The concurrent employment of α-amino acid-derived chiral components such as aldehydes and α-isocyanoacetates, in a sequential Ugi reaction/cyclization two-step strategy, opens the door to the synthesis of three structurally ...
    • Assessment of diagnostic enzyme-linked immunosorbent assay kit and serological markers in human brucellosis 

      Cakan G.; Bezirci F.B.; Kacka, A.; Cesur, S.; Aksaray, S.; Tezeren, D.; Saka, D.; Ahmed, K. (2008)
      This study was performed to evaluate commercial brucella immunoglobulin G and M-enzymelinked immunosorbent assay (IgG and IgM ELISA) kits for the diagnosis of human brucellosis and to suggest a candidate prognostic marker ...
    • Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes 

      Akturk, M.; Altinova, A.; Mert I.; Dincel, A.; Sargin, A.; Buyukkagnici, U.; Arslan, M.; Danisman, N. (2010)
      As shown in the previous studies, asymmetric dimethylarginine (ADMA) is related to endothelial dysfunction, whereas high-sensitive C-reactive protein (hCRP) is the marker of inflammation. In our study, we investigated ADMA, ...
    • Audiovisual associations alter the perception of low-level visual motion 

      Kafaligonul H.; Oluk, C. (Frontiers Research Foundation, 2015)
      Motion perception is a pervasive nature of vision and is affected by both immediate pattern of sensory inputs and prior experiences acquired through associations. Recently, several studies reported that an association can ...
    • Benzothiazole derivatives as human DNA topoisomerase IIα inhibitors 

      Kaplan-Ozen, C.; Tekiner-Gulbas, B.; Foto, E.; Yildiz I.; Diril, N.; Aki, E.; Yalcin I. (2013)
      Benzothiazole derivatives resembling the structure of DNA purine bases were tested to determine their topoisomerase inhibition activities. Based on DNA topoisomerase I and II relaxation assay results, all 12 derivatives ...
    • Beyond the 'East-West' dichotomy: Global variation in cultural models of selfhood 

      Vignoles, V. L.; Owe, E.; Becker, M.; Smith, P. B.; Easterbrook, M. J.; Brown, R.; González, R.; Didier, N.; Carrasco, D.; Cadena, M. P.; Lay, S.; Schwartz, S. J.; Rosiers, S. E. D.; Villamar, J. A.; Gavreliuc, A.; Zinkeng, M.; Kreuzbauer, R.; Baguma, P.; Martin, M.; Tatarko, A.; Herman, G.; de Sauvage, I.; Courtois, M.; Gardarsdóttir, R. B.; Harb, C.; Gallo, I. S.; Gil, P. P.; Clemares, R. L.; Campara, G.; Nizharadze, G.; Macapagal, M. E. J.; Jalal, B.; Bourguignon, D.; Zhang, J.; Lv, S.; Chybicka, A.; Yuki, M.; Zhang X.; Espinosa, A.; Valk, A.; Abuhamdeh, S.; Amponsah, B.; Özgen E.; Guner, E. Ü.; Yamakoglu, N.; Chobthamkit, P.; Pyszczynski, T.; Kesebir, P.; Trujillo, E. V.; Balanta, P.; Ayala, B. C.; Koller, S. H.; Jaafar, J. L.; Gausel, N.; Fischer, R.; Milfont, T. L.; Kusdil, E.; Çağlar, S.; Aldhafri, S.; Ferreira, M. C.; Mekonnen, K. H.; Wang, Q.; Fülöp, M.; Torres, A.; Camino, L.; Lemos, F. C. S.; Fritsche, I.; Möller, B.; Regalia, C.; Manzi, C.; Brambilla, M.; Bond, M. H. (American Psychological Association Inc., 2016)
      Markus and Kitayama's (1991) theory of independent and interdependent self-construals had a major influence on social, personality, and developmental psychology by highlighting the role of culture in psychological processes. ...
    • The bonobo genome compared with the chimpanzee and human genomes 

      Prüfer, K.; Munch, K.; Hellmann I.; Akagi, K.; Miller J.R.; Walenz, B.; Koren, S.; Sutton G.; Kodira, C.; Winer, R.; Knight J.R.; Mullikin J.C.; Meader, S.J.; Ponting, C.P.; Lunter G.; Higashino, S.; Hobolth, A.; Dutheil J.; Karakoç, E.; Alkan, C.; Sajjadian, S.; Catacchio, C.R.; Ventura, M.; Marques-Bonet, T.; Eichler, E.E.; André, C.; Atencia, R.; Mugisha L.; Junhold J.; Patterson, N.; Siebauer, M.; Good J.M.; Fischer, A.; Ptak, S.E.; Lachmann, M.; Symer, D.E.; Mailund, T.; Schierup, M.H.; Andrés, A.M.; Kelso J.; Pääbo, S. (2012)
      Two African apes are the closest living relatives of humans: the chimpanzee (Pan troglodytes) and the bonobo (Pan paniscus). Although they are similar in many respects, bonobos and chimpanzees differ strikingly in key ...
    • Cd81 Interacts with the T Cell Receptor to Suppress Signaling 

      Cevik, S.I.; Keskin, N.; Belkaya, S.; Ozlu, M.I.; Deniz, E.; Tazebay, U.H.; Erman, B. (2012)
      CD81 (TAPA-1) is a ubiquitously expressed tetraspanin protein identified as a component of the B lymphocyte receptor (BCR) and as a receptor for the Hepatitis C Virus. In an effort to identify trans-membrane proteins that ...
    • Choroid Plexus Papillomas in two Siblings: Case Report 

      Okay O.; Daglioglu, E.; Yakicier, C.; Uren, D.; Dalgic, A.; Ergungor F. (2009)
      Choroid plexus papilloma (CPP) is a rare, benign epithelial brain tumor of the nervous system seen particularly in infants. Familial cases are extremely uncommon. Some other form of malignant tumors was noted in the relatives ...
    • Chronic pain and selective attention to pain arousing daily activity pictures: Evidence from an eye tracking study 

      Mahmoodi-Aghdam M.; Dehghani M.; Ahmadi M.; Banaraki A.K.; Khatibi A. (Iran University of Medical Sciences, 2017)
      Introduction: According to the pain research literature, attentional bias for pain is the mechanism responsible for the development and maintenance of fear of pain in patients with chronic pain. However, there is still ...
    • Cognitive individualism and the child as scientist program 

      Wringe, B. (2011)
      In this paper, I examine the charge that Gopnik and Meltzoff's 'Child as Scientist' program, outlined and defended in their 1997 book Words, Thoughts and Theories is vitiated by a form of 'cognitive individualism' about ...
    • Coiled-Coil Domain Containing Protein 124 Is a Novel Centrosome and Midbody Protein That Interacts with the Ras-Guanine Nucleotide Exchange Factor 1B and Is Involved in Cytokinesis 

      Telkoparan P.; Erkek, S.; Yaman, E.; Alotaibi H.; Bayik, D.; Tazebay, U.H. (2013)
      Cytokinetic abscission is the cellular process leading to physical separation of two postmitotic sister cells by severing the intercellular bridge. The most noticeable structural component of the intercellular bridge is a ...
    • Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations 

      Cevik, D.; Yildiz G.; Ozturk, M. (WJG Press, 2015)
      AIM: To determine the mutation status of human telomerase reverse transcriptase gene (TERT ) promoter region in hepatocellular carcinoma (HCC) from different geographical regions. METHODS: We analyzed the genomic DNA ...
    • Comparison of original EuroSCORE, EuroSCORE II and STS risk models in a Turkish cardiac surgical cohort 

      Kunt, A.G.; Kurtcephe, M.; Hidiroglu, M.; Cetin L.; Kucuker, A.; Bakuy V.; Ruchan Akar, A.; Sener, E. (2013)
      OBJECTIVESThe aim of this study was to compare additive and logistic European System for Cardiac Operative Risk Evaluation (EuroSCORE), EuroSCORE II and the Society of Thoracic Surgeons (STS) models in calculating mortality ...
    • A comprehensive methodology for determining the most informative mammographic features 

      Wu, Y.; Alagoz O.; Ayvaci, M.U.S.; Munoz Del Rio, A.; Vanness, D.J.; Woods, R.; Burnside, E.S. (2013)
      This study aims to determine the most informative mammographic features for breast cancer diagnosis using mutual information (MI) analysis. Our Health Insurance Portability and Accountability Act-approved database consists ...
    • Cost-effectiveness of adjuvant FOLFOX and 5FU/LV chemotherapy for patients with stage II colon cancer 

      Ayvaci, M.U.S.; Shi J.; Alagoz O.; Lubner, S.J. (2013)
      Purpose. We evaluated the cost-effectiveness of adjuvant chemotherapy using 5-fluorouracil, leucovorin (5FU/LV), and oxaliplatin (FOLFOX) compared with 5FU/LV alone and 5FU/LV compared with observation alone for patients ...
    • Cytotoxic activities of some benzothiazole-piperazine derivatives 

      Gurdal, E.E.; Durmaz I.; Cetin-Atalay, R.; Yarim, M. (Taylor and Francis Ltd, 2015)
      Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and ...