Now showing items 1-5 of 5

    • Anti-cancer and anti-hepatitis C virus NS5B polymerase activity of etodolac 1,2,4-triazoles 

      Çikla-Süzgün P.; Kaushik-Basu, N.; Basu, A.; Arora P.; Talele, T.T.; Durmaz I.; Çetin-Atalay, R.; Küçükgüzel, S.G. (Taylor and Francis Ltd, 2015)
      Arachidonic acid is an unsaturated fatty acid liberated from phospholipids of cell membranes. NSAIDs are known as targets of cyclooxygenase enzyme (COX-1, COX-2 and COX-3) in arachidonic acid metabolism. This mechanism of ...
    • Characterization of cancer stem cells in hepatocellular carcinoma 

      Abdüsselamoğlu, Merve Deniz (Bilkent University, 2014)
      Hepatocellular carcinoma (HCC) is the third most common cause of death from cancer worldwide due to the challenges in both its diagnosis and treatment. According to recent studies, HCC tumors, like many other solid tumors ...
    • In silico analysis of mutant p53(R249S) oncogenicity in hepatocellular carcinoma 

      Ovezmuradov, Guvanchmurad (Bilkent University, 2007)
      Oncogenic properties of mutant p53 proteins still stand as an ill-known subject, and the mechanism responsible for this phenomenon remains to be uncovered. This thesis aims to uncover the effect of p53 codon R249S ...
    • Mineralocorticoid and glucocorticoid receptors as novel targets in breast and liver cancer therapies 

      Güneş, Damla (Bilkent University, 2021-01)
      Cell signaling is a complex phenomenon and is maintained through intertwined signal transmissions within and in-between the cells. Anti-cancer therapies are often challenged by this fact due to crosstalk-associated ...
    • Role of JMJD5 in liver cancer 

      Demirdizen, Engin (Bilkent University, 2013)
      Being one of the most common cancer types in human population, hepatocellular carcinoma (HCC) has high rate of deaths due to the challenges in its diagnosis and treatment. In recent years, epigenetic regulators have come ...