Now showing items 1-4 of 4

    • De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder 

      Dong, S.; Walker, M.F.; Carriero, N.J.; DiCola, M.; Willsey, A.; Ye, A.Y.; Waqar, Z.; Gonzalez L.E.; Overton J.D.; Frahm, S.; Keaney J.F.; III, Teran, N.A.; Dea J.; Mandell J.D.; HusBal V.; Sullivan, C.A.; DiLullo, N.M.; Khalil, R.O.; Gockley J.; Yuksel, Z.; Sertel, S.M.; Ercan-Sencicek, A.G.; Gupta, A.R.; Mane, S.M.; Sheldon, M.; Brooks, A.I.; Roeder, K.; Devlin, B.; State, M.W.; Wei L.; Sanders, S.J. (Elsevier, 2014)
      Whole-exome sequencing (WES) studies have demonstrated the contribution of de novo loss-of-function single-nucleotide variants (SNVs) to autism spectrum disorder (ASD). However, challenges in the reliable detection of de ...
    • PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas 

      Acun, T.; Demir, K.; Oztas, E.; Arango, D.; Yakicier, M.C. (Mary Ann Liebert Inc., 2015)
      PTPRD (protein tyrosine phosphatase, receptor type, D) is a tumor suppressor gene, frequently inactivated through deletions or epigenetic mechanisms in several cancers with importance for global health. In this study, we ...
    • A role for LYNX2 in anxiety-related behavior 

      Tekinay, A.B.; Nong, Y.; Miwa J.M.; Lieberam I.; Ibanez-Tallon I.; Greengard P.; Heintz, N. (2009)
      Anxiety disorders are the most prevalent mental disorders in developed societies. Although roles for the prefrontal cortex, amygdala, hippocampus and mediodorsal thalamus in anxiety disorders are well documented, molecular ...
    • SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation 

      Acun, T.; Oztas, E.; Yagci, T.; Yakicier, M.C. (2011)
      Background: Smad interacting protein-1 is a transcription factor that is implicated in transforming growth factor-β/bone morphogenetic protein signaling and a repressor of E-cadherin and human telomerase reverse transcriptase. ...