Now showing items 1-5 of 5

    • Imetelstat (a telomerase antagonist) exerts off target effects on the cytoskeleton 

      Mender I.; Senturk, S.; Ozgunes, N.; Can Akcali, K.; Kletsas, D.; Gryaznov, S.; Can, A.; Shay J.W.; Dikmen, Z.G. (2013)
      Telomerase is a cellular ribonucleoprotein reverse transcriptase that plays a crucial role in telomere maintenance. This enzyme is expressed in approximately 90% of human tumors, but not in the majority of normal somatic ...
    • MST1 is a multifunctional caspase-independent inhibitor of androgenic signaling 

      Cinar, B.; Collak F.K.; Lopez, D.; Akgul, S.; Mukhopadhyay, N.K.; Kilicarslan, M.; Gioeli, D.G.; Freeman, M.R. (2011)
      The MST1 serine - threonine kinase, a component of the RASSF1-LATS tumor suppressor network, is involved in cell proliferation and apoptosis and has been implicated in cancer. However, the physiologic role of MST1 in ...
    • Serum adenosine deaminase levels in patients with brucellosis and in healthy subjects 

      Cesur, S.; Sunguroǧlu, K.; Ahmed, K.; Tezeren, D.; Keseci, N.O.; Aksaray, S. (2004)
      The aim of this study was to determine the serum adenosine deaminase (ADA) levels in patients with brucellosis and compare them with the results of healthy individuals. Forty-eight subject were enrolled in this study : 34 ...
    • The spontaneous hemin release form Lumbricus terrestris hemoglobin 

      Smith, M.L.; Paul J.; Ohlsson P.I.; Paul, K.G. (1997)
      The slow, spontaneous release of hemin from earthworm, Lumbricus terrestris, hemoglobin has been studied under mild conditions in the presence of excess apomyoglobin. This important protein is surprisingly unstable. The ...
    • Ynamide Click chemistry in development of triazole VEGFR2 TK modulators 

      Vojtičková, M.; Dobiaš J.; Hanquet G.; Addová G.; Cetin-Atalay, R.; Yildirim, D.C.; Boháč, A. (Elsevier Masson SAS, 2015)
      Structure novelty, chemical stability and synthetic feasibility attracted us to design 1,2,3-triazole compounds as potential inhibitors of VEGFR2 tyrosine kinase. Novel triazoles T1-T7 were proposed by oxazole (AAZ from ...