Now showing items 1-4 of 4

    • Imetelstat (a telomerase antagonist) exerts off target effects on the cytoskeleton 

      Mender I.; Senturk, S.; Ozgunes, N.; Can Akcali, K.; Kletsas, D.; Gryaznov, S.; Can, A.; Shay J.W.; Dikmen, Z.G. (2013)
      Telomerase is a cellular ribonucleoprotein reverse transcriptase that plays a crucial role in telomere maintenance. This enzyme is expressed in approximately 90% of human tumors, but not in the majority of normal somatic ...
    • PATZ1 is a DNA damage-responsive transcription factor that inhibits p53 function 

      Keskin, N.; Deniz, E.; Eryilmaz J.; Un, M.; Batur, T.; Ersahin, T.; Atalay, R.C.; Sakaguchi, S.; Ellmeier W.; Erman, B. (American Society for Microbiology, 2015)
      Insults to cellular health cause p53 protein accumulation, and loss of p53 function leads to tumorigenesis. Thus, p53 has to be tightly controlled. Here we report that the BTB/POZ domain transcription factor PATZ1 (MAZR), ...
    • Peptide nanofiber scaffolds for multipotent stromal cell culturing 

      Ustun, S.; Kocabey, S.; Guler, M.O.; Tekinay, A.B. (Humana Press Inc., 2013)
      Self-assembled peptide nanofibers are versatile materials providing suitable platforms for regenerative medicine applications. This chapter describes the use of peptide nanofibers as extracellular matrix mimetic scaffolds ...
    • Texturing of titanium (Ti6Al4V) medical implant surfaces with MHz-repetition-rate femtosecond and picosecond Yb-doped fiber lasers 

      Erdoǧan, M.; Öktem, B.; Kalaycioǧlu H.; Yavaş, S.; Mukhopadhyay P.K.; Eken, K.; Özgören, K.; Aykaç, Y.; Tazebay, U.H.; Ilday F.O. (Optical Society of American (OSA), 2011)
      We propose and demonstrate the use of short pulsed fiber lasers in surface texturing using MHz-repetition-rate, microjoule- and sub-microjoule-energy pulses. Texturing of titanium-based (Ti6Al4V) dental implant surfaces ...