Browsing by Keywords "Vaccine"
Now showing items 1-16 of 16
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Biotin functionalized self‐assembled peptide nanofiber as an adjuvant for immunomodulatory response
(Wiley-VCH Verlag, 2020-12)Biotinylated peptide amphiphile (Biotin‐PA) nanofibers, are designed as a noncovalent binding location for antigens, which are adjuvants to enhance, accelerate, and prolong the immune response triggered by antigens. ... -
Development & characterization of CpG adjuvanted SARS-CoV-2 Virus-Like Particle vaccine
(Bilkent University, 2022-06)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appeared in late 2019, led to countless cases and deaths and eventually regarded as one of the severe pandemics of modern times. To reduce hospitalization and ... -
Development and preclinical evaluation of virus-like particle vaccine against COVID-19 infection
(Wiley-Blackwell Publishing Ltd., 2021-09-14)Background Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes the development and immunogenicity of SARS-CoV-2 VLP ... -
Differential immune activation following encapsulation of immunostimulatory CpG oligodeoxynucleotide in nanoliposomes
(Elsevier, 2011)The immunogenicity of a vaccine formulation is closely related to the effective internalization by the innate immune cells that provide prolonged and simultaneous delivery of antigen and adjuvant to relevant antigen ... -
Erken Cumhuriyet ve II. Dünya Savaşı yıllarında Türkiye’de görülen salgın hastalıklar ve mücadele yöntemleri
(Bilkent University, 2020)Türkiye Cumhuriyeti kurulduğunda, uzun süren savaşlar sebebiyle harabe haline gelen Anadolu’da bir yandan verem, tifüs, sıtma, trahom, frengi gibi bulaşıcı hastalıklarla mücadele ediliyordu. Cumhuriyet’in ilanıyla birlikte ... -
Immunomodulatory effects of TLR ligands and polysaccharide combinations : strategies to augment innate immune response
(Bilkent University, 2007)Microbial infection initiates multiple TLR ligand mediated signaling cascade on innate immune cells. While some TLRs trigger a Th1 biased immune activation, others may lead to a Th2 dominant immune response. Extracellular ... -
Immunoregulatory activities of nanoparticle-forming oligodeoxynucleotides
(Bilkent University, 2009)Innate immune system is activated by a wide range of microbial by products leading to an immediate immune activation primarily designed to neutralize and control the invading insult. The cells of the innate immune system ... -
In vivo applications of liposomal vaccines encapsulating single or dual pathogenassociated molecular patterns
(Bilkent University, 2017-03)Nucleic acid-based pattern recognition receptor (PRR) agonists are promising adjuvants and immunotherapeutic agents. Combination of PRR ligands potentiates immune response by providing synergistic immune activity via ... -
Induction of potent protection against acute and latent herpes simplex virus infection in mice vaccinated with dendritic cells
(2013)Background aims. Dendritic cells (DCs) are the most potent antigen presenting cells of the immune system and have been under intense study with regard to their use in immunotherapy against cancer and infectious disease ... -
Investigation of cellular and humoral immune responses induced by SARS-CoV-2 VLP vaccine in Pre-clinical and clinical studies
(Bilkent University, 2022-08)COVID-19 pandemic, caused by SARS-CoV-2, emerged in China in late 2019, and as of March 2020 has become a serious concern for the whole world due to severe progression of the disease especially in the elderly and high ... -
Investigation of improved immunostimulatory activity of D and K type CpG ODNs in liposomes
(Bilkent University, 2013)CpG ODNs are potent immunotherapeutic agents. In human, two major classes of CpG ODNs were shown to induce differential immune activation. D ODNs are strong IFNα inducers, thus promising antiviral agents, whereas K ODNs ... -
Investigation of Pre-clinical and clinical results against SARS-COV-2 wild-type and Alpha variants combination of VLP-58-1023-AL-K3 vaccine
(Bilkent University, 2022-08)The SARS-CoV-2 virus, which first appeared in Wuhan, China and had a pandemic effect at the end of 2019, has urgently created need of suitable vaccine candidates’ development with its quick spread. Scientists in different ... -
Large-scale manufacturing and characterization of a Sars Cov-2 virus-like particle vaccine adsorbed onto alhydrogel and adjuvanted with K3 CpG oligodeoxynucleotide for use in phase 1/2 clinical trials
(Bilkent University, 2022-04-28)Emergence of COVID-19 pandemic has been met by an exceptionally fast response from vaccine makers around the globe. Vaccines that elicit excellent immunological responses against SARS-CoV-2 are now widely utilized. ... -
Modulation of immune responses using adjuvants to facilitate therapeutic vaccination
(Wiley, 2020)Therapeutic vaccination offers great promise as an intervention for a diversity of infectious and non‐infectious conditions. Given that most chronic health conditions are thought to have an immune component, vaccination ... -
Osmanlı’da ve Türkiye’de aşı tarihi
(Bilkent University, 2020)Aşılar toplum sağlığının korunmasının önemli bir parçasıdır. Aşılanmış bir toplum salgınlara karşı da bağışıklık kazanmış olur. Hem Osmanlı devletinde hem de Türkiye Cumhuriyeti'nde toplum sağlığını korumak ve salgınlarla ... -
Rational vaccine design in times of emerging diseases: The critical choices of immunological correlates of protection, vaccine antigen and immunomodulation
(MDPI AG, 2021-04-06)Vaccines are the most effective medical intervention due to their continual success in preventing infections and improving mortality worldwide. Early vaccines were developed empirically however, rational design of vaccines ...
