Browsing by Keywords "Up-regulation"
Now showing items 1-2 of 2
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CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1
(The American Society for Biochemistry and Molecular Biology, Inc., 2012)Interleukin-7 receptor α (IL-7Rα) is essential for T cell survival and differentiation. Glucocorticoids are potent enhancers of IL-7Rα expression with diverse roles in T cell biology. Here we identify the transcriptional ... -
Senescence and immortality in hepatocellular carcinoma
(Elsevier, 2009-10-01)Cellular senescence is a process leading to terminal growth arrest with characteristic morphological features. This process is mediated by telomere-dependent, oncogene-induced and ROS-induced pathways, but persistent DNA ...