Now showing items 1-20 of 70

    • 15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1 

      Tunçer, S.; Keşküş, A. G.; Çolakoğlu, M.; Çimen, I.; Yener, C.; Konu, Ö.; Banerjee, S. (Elsevier, 2017-11)
      15-lipoxygenase-1 (15-LOX-1) oxygenates linoleic acid to 13(S)-hydroxyoctadecadienoic acid (HODE). The enzyme is widely suppressed in different cancers and its re-expression has tumor suppressive effects. 15-LOX-1 has been ...
    • Adjuvant autologous melanoma vaccine for macroscopic stage III disease: survival, biomarkers, and improved response to CTLA-4 blockade 

      Lotem, M.; Merims, S.; Frank, S.; Hamburger, T.; Nissan, A.; Kadouri, L.; Cohen, J.; Straussman, R.; Eisenberg, G.; Frankenburg, S.; Carmon, E.; Alaiyan, B.; Shneibaum, S.; Ayyildiz, Z. O.; Isbilen, M.; Senses, K. M.; Ron, I.; Steinberg, H.; Smith, Y.; Shiloni, E.; Gure, A. O.; Peretz, T. (Hindawi Limited, 2016)
      Background. There is not yet an agreed adjuvant treatment for melanoma patients with American Joint Committee on Cancer stages III B and C. We report administration of an autologous melanoma vaccine to prevent disease ...
    • Alternatively spliced Robo2 isoforms in zebrafish and rat 

      Dalkic, E.; Kuscu, C.; Sucularli, C.; Aydin, I. T.; Akcali, K. C.; Konu, O. (Springer-Verlag, 2006)
      Robo2, a member of the robo gene family, functions as a repulsive axon guidance receptor as well as a regulator of cell migration and tissue morphogenesis in different taxa. In this study, a novel isoform of the zebrafish ...
    • Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias 

      Akyerli, C. B.; Özbek, U.; Aydin-Sayitoǧlu, M.; Sirma, S.; Özçelik, T. (Springer, 2003)
      [No abstract available]
    • Angiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute wounds 

      Uzunalli, G.; Mammadov R.; Yesildal, F.; Alhan, D.; Ozturk, S.; Ozgurtas, T.; Guler, M. O.; Tekinay, A. B. (American Chemical Society, 2017)
      Wound repair in adult mammals typically ends with the formation of a scar, which prevents full restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of ...
    • Angiogenic peptide nanofibers improve wound healing in STZ-induced diabetic rats 

      Senturk, B.; Mercan, S.; Delibasi, T.; Guler, M. O.; Tekinay, A. B. (American Chemical Society, 2016-06)
      Low expressions of angiogenic growth factors delay the healing of diabetic wounds by interfering with the process of blood vessel formation. Heparin mimetic peptide nanofibers can bind to and enhance production and activity ...
    • Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes 

      Celebioglu A.; Umu, O. C. O.; Tekinay, T.; Uyar T. (Elsevier, 2014)
      The electrospinning of nanofibers (NF) from cyclodextrin inclusion complexes (CD-IC) with an antibacterial agent (triclosan) was achieved without using any carrier polymeric matrix. Polymer-free triclosan/CD-IC NF were ...
    • Biosystems engineering of prokaryotes with tumor-killing capacities 

      Kalyoncu, E.; Olmez, T. T.; Ozkan, A. D.; Sarioglu, O. F. (Bentham Science Publishers Ltd., 2016)
      Certain bacteria selectively attack tumor tissues and trigger tumor shrinkage by producing toxins and modulating the local immune system, but their clinical utility is limited because of the dangers posed by systemic ...
    • Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells 

      Yuzugullu, H.; Benhaj, K.; Ozturk, N.; Senturk, S.; Celik, E.; Toylu, A.; Tasdemir, N.; Yilmaz, M.; Erdal, E.; Akcali, K. C.; Atabey, N.; Ozturk, M. (BioMed Central, 2009)
      Background: β-catenin mutations that constitutively activate the canonical Wnt signaling have been observed in a subset of hepatocellular carcinomas (HCCs). These mutations are associated with chromosomal stability, low ...
    • The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data 

      Cerami, E.; Gao, J.; Dogrusoz, U.; Gross, B. E.; Sumer, S. O.; Aksoy, B. A.; Jacobsen, A.; Byrne, C. J.; Heuer, M. L.; Larsson, E.; Antipin, Y.; Reva, B.; Goldberg, A. P.; Sander, C.; Schultz, N. (American Association for Cancer Research, 2012-05)
      The cBio Cancer Genomics Portal (http://cbioportal.org) is an open-access resource for interactive exploration of multidimensional cancer genomics data sets, currently providing access to data from more than 5,000 tumor ...
    • Chromatin-modifying enzymes as modulators of reprogramming 

      Onder, T. T.; Kara, N.; Cherry, A.; Sinha, A. U.; Zhu, N.; Bernt, K. M.; Cahan, P.; Marcarci, B. O.; Unternaehrer, J.; Gupta, P. B.; Lander, E. S.; Armstrong, S. A.; Daley, G. Q. (Nature Publishing Group, 2012)
      Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming involves global epigenetic remodelling. Whereas several proteins are known to regulate chromatin marks associated with the distinct epigenetic ...
    • Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet's disease severity 

      Kahraman, T.; Gucluler, G.; Simsek, I.; Yagci, F. C.; Yildirim, M.; Ozen, C.; Dinc, A.; Gursel, M.; Ikromzoda, L.; Sutlu, T.; Gay, S.; Gursel, I. (Taylor and Francis, 2017-02)
      Behçet's disease (BD) activity is characterised by sustained, over-exuberant immune activation, yet the underlying mechanisms leading to active BD state are poorly defined. Herein, we show that the human cathelicidin derived ...
    • Colon cancer associated transcript-1 (CCAT1) expression in adenocarcinoma of the stomach 

      Mizrahi, I.; Mazeh, H.; Grinbaum, R.; Beglaibter, N.; Wilschanski, M.; Pavlov, V.; Adileh, M.; Stojadinovic, A.; Avital, I.; Gure, A. O.; Halle, D.; Nissan, A. (Ivyspring International Publisher, 2015)
      Background: Long non-coding RNAs (lncRNAs) have been shown to have functional roles in cancer biology and are dys-regulated in many tumors. Colon Cancer Associated Transcript -1 (CCAT1) is a lncRNA, previously shown to be ...
    • A combined ULBP2 and SEMA5A expression signature as a prognostic and predictive biomarker for colon cancer 

      Demirkol, S.; Gomceli, I.; Isbilen, M.; Dayanc, B. E.; Tez, M.; Bostanci, E. B.; Turhan, N.; Akoglu, M.; Ozyerli, E.; Durdu, S.; Konu, O.; Nissan, A.; Gonen, M.; Gure, A. O. (Ivyspring International Publisher, 2017)
      Background: Prognostic biomarkers for cancer have the power to change the course of disease if they add value beyond known prognostic factors, if they can help shape treatment protocols, and if they are reliable. The aim ...
    • Cornea engineering on polyester carriers 

      Zorlutuna, P.; Tezcaner, A.; Kiyat, I.; Aydinli, A.; Hasirci, V. (John Wiley & Sons, Inc., 2006)
      In this study, biodegradable polyester based carriers were designed for tissue engineering of the epithelial and the stromal layers of the cornea, and the final construct was tested in vitro. In the construction of the ...
    • Cytotoxic and bioactive properties of different color tulip flowers and degradation kinetic of tulip flower anthocyanins 

      Sagdic, O.; Ekici, L.; Ozturk, I.; Tekinay, T.; Polat, B.; Tastemur, B.; Bayram, O.; Senturk, B. (Pergamon Press, 2013)
      This study was conducted to determine the potential use of anthocyanin-based extracts (ABEs) of wasted tulip flowers as food/drug colorants. For this aim, wasted tulip flowers were samples and analyzed for their bioactive ...
    • Determining the origin of synchronous multifocal bladder cancer by exome sequencing 

      Acar, Ö.; Özkurt, E.; Demir, G.; Saraç, H.; Alkan C.; Esen, T.; Somel, M.; Lack, N. A. (BioMed Central Ltd., 2015)
      Background: Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration ...
    • Differential expression patterns of metastasis suppressor proteins in basal cell carcinoma 

      Bozdogan, O.; Yulug, I. G.; Vargel, I.; Cavusoglu, T.; Karabulut, A. A.; Karahan, G.; Sayar, N. (Wiley-Blackwell Publishing Ltd., 2015)
      Background: Basal cell carcinomas (BCCs) are common malignant skin tumors. Despite having a significant invasion capacity, they metastasize only rarely. Our aim in this study was to detect the expression patterns of the ...
    • Dispersion of multi-walled carbon nanotubes in an aqueous medium by water-dispersible conjugated polymer nanoparticles 

      Baykal, B.; Ibrahimova, V.; Er, G.; Bengü, E.; Tuncel, D. (2010)
      Vertically aligned multi-walled carbon nanotubes (MWCNTs) synthesized by the alcohol catalytic CVD (ACCVD) technique are dispersed in water with the aid of water-dispersible conjugated polymer nanoparticles (CPNs). The ...
    • DNA repair gene polymorphisms and bladder cancer susceptibility in a Turkish population 

      Karahalil, B.; Kocabas, N. A.; Özçelik, T. (International Institute of Anticancer Research, 2006)
      Background: Occupational exposure and life style preferences, such as smoking are the main known environmental susceptibility factors for bladder cancer. A growing list of chemicals has been shown to induce oxidative DNA ...