Now showing items 1-6 of 6

    • Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter 

      Carreira, S.; Dexter, T. J.; Yavuzer, U.; Easty, D. J.; Goding, C. R. (1998)
      Previous work has demonstrated that two key melanocyte-specific elements termed the MSEu and MSEi play critical roles in the expression of the melanocyte-specific tyrosinase-related protein 1 (TRP-1) promoter. Both the ...
    • Discovering modulators of gene expression 

      Babur, Ö.; Demir, E.; Gönen, M.; Sander, C.; Dogrusoz, U. (Oxford University Press, 2010)
      Proteins that modulate the activity of transcription factors, often called modulators, play a critical role in creating tissue- and context-specific gene expression responses to the signals cells receive. GEM (Gene Expression ...
    • Distinct regulation of tonsillar immune response in virus infection 

      Jartti, T.; Palomares, O.; Waris, M.; Tastan, O.; Nieminen, R.; Puhakka, T.; Rückert, B.; Aab, A.; Vuorinen, T.; Allander, T.; Vahlberg, T.; Ruuskanen, O.; Akdis, M.; Akdis, C. A. (Wiley-Blackwell Publishing Ltd., 2014)
      Background: The relationships between tonsillar immune responses, and viral infection and allergy are incompletely known. Objective To study intratonsillar/nasopharyngeal virus detections and in vivo expressions of T-cell- ...
    • Functionally conserved effects of rapamycin exposure on zebrafish 

      Sucularli, C.; Shehwana, H.; Kuscu, C.; Dungul, D. C.; Ozdag, H.; Konu, O. (Spandidos Publications, 2016-03)
      Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase important in cell proliferation, growth and protein translation. Rapamycin, a well-known anti-cancer agent and immunosuppressant drug, inhibits ...
    • Pax3 and regulation of the melanocyte-specific tyrosinase-related protein-1 promoter 

      Galibert, M. D.; Yavuzer, U.; Dexter, T. J.; Goding, C. R. (1999)
      Previous work has established that the melanocyte-specific tyrosinase- related protein-1 (TRP-1) promoter is regulated positively by the microphthalmia-associated transcription factor Mitf, acting through the conserved M ...
    • Quinoides and VEGFR2 TKIs influence the fate of hepatocellular carcinoma and its cancer stem cells 

      Kahraman, D. C.; Hanquet, G.; Jeanmart, L.; Lanners, S.; Šramel, P.; Boháč, A.; Cetin-Atalay, R. (Royal Society of Chemistry, 2017)
      Bioactivities of quinoides 1–5 and VEGFR2 TKIs 6–10 in hepatocellular cancer (HCC) and cancer stem cells (HCSCs) were studied. The compounds exhibited IC50 values in μM concentrations in HCC cells. Quinoide 3 was able to ...