Browsing by Keywords "Tissue engineering"
Now showing items 1-18 of 18
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Chemical and topographical modification of PHBV surface to promote osteoblast alignment and confinement
(John Wiley & Sons, Inc., 2008)Proper cell attachment and distribution, and thus stronger association in vivo between a bone implant and native tissue will improve the success of the implant. In this study, the aim was to achieve promotion of attachment ... -
Contact guidance enhances the quality of a tissue engineered corneal stroma
(John Wiley & Sons, Inc., 2008)Corneal stroma is a very complex structure, composed of 200 lamellae of oriented collagen fibers. This highly complex nature of cornea is known to be important for its transparency and mechanical integrity. Thus, an ... -
Cornea engineering on polyester carriers
(John Wiley & Sons, Inc., 2006)In this study, biodegradable polyester based carriers were designed for tissue engineering of the epithelial and the stromal layers of the cornea, and the final construct was tested in vitro. In the construction of the ... -
Design and fabrication of auxetic PCL nanofiber membranes for biomedical applications
(Elsevier, 2017-12)The main objective of this study was to fabricate poly (ε-caprolactone) (PCL)-based auxetic nanofiber membranes and characterize them for their mechanical and physicochemical properties. As a first step, the PCL nanofibers ... -
Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers
(Elsevier, 2014)In this study, we select naproxen (NAP) as a reference drug and electrospun poly (e-caprolactone) (PCL) nanofibers as a fibrous matrix for our drug-delivery system. NAP was complexed with beta-cyclodextrin (βCD) to form ... -
Electrostatic effects on nanofiber formation of self-assembling peptide amphiphiles
(Elsevier, 2011)Self-assembling peptide amphiphile molecules have been of interest to various tissue engineering studies. These molecules self-assemble into nanofibers which organize into three-dimensional networks to form hydrocolloid ... -
Glycosaminoglycan-Mimetic Signals Direct the Osteo/Chondrogenic Differentiation of Mesenchymal Stem Cells in a Three-Dimensional Peptide Nanofiber Extracellular Matrix Mimetic Environment
(American Chemical Society, 2016-02)Recent efforts in bioactive scaffold development focus strongly on the elucidation of complex cellular responses through the use of synthetic systems. Designing synthetic extracellular matrix (ECM) materials must be based ... -
Graph walks for classification of histopathological images
(2013)This paper reports a new structural approach for automated classification of histopathological tissue images. It has two main contributions: First, unlike previous structural approaches that use a single graph for representing ... -
Nanoengineering hybrid supramolecular multilayered biomaterials using polysaccharides and self-assembling peptide amphiphiles
(Wiley-VCH Verlag, 2017)Developing complex supramolecular biomaterials through highly dynamic and reversible noncovalent interactions has attracted great attention from the scientific community aiming key biomedical and biotechnological applications, ... -
One-Step Fabrication of Biocompatible Multifaceted Nanocomposite Gels and Nanolayers
(American Chemical Society, 2017)Nanocomposite gels are a fascinating class of polymeric materials with an integrative assembly of organic molecules and organic/inorganic nanoparticles, offering a unique hybrid network with synergistic properties. The ... -
Peptide-based bioinspired functional materials
(Bilkent University, 2016-12)Ability of nature to build complex systems via step-by-step addition of small building blocks with distinctive qualities and multi-functionalities has garnered massive attention which gave a rise to biomimetic or biologically ... -
Preparation and characterization of poly(hydroxyethyl methacrylate-co-poly(ethyleneglycol-methacrylate)/hydroxypropyl-chitosan) hydrogel films: Adhesion of rat mesenchymal stem cells
(Hangug Gobunja Haghoi, 2010-12-02)This study examined the effects of the surface properties of the materials, such as the hydroxyl, methyl and amino groups, on rat bone marrow derived Mesenchymal Stem Cell (MSC) seeding. A series of hydrogels were prepared ... -
Self-assembled peptide amphiphile nanofibers and PEG composite hydrogels as tunable ECM mimetic microenvironment
(American Chemical Society, 2015)(Figure Presented). Natural extracellular matrix (ECM) consists of complex signals interacting with each other to organize cellular behavior and responses. This sophisticated microenvironment can be mimicked by advanced ... -
Self-assembled proteins and peptides as scaffolds for tissue regeneration
(Wiley-VCH Verlag, 2015)Self-assembling proteins and peptides are increasingly gaining interest for potential use as scaffolds in tissue engineering applications. They self-organize from basic building blocks under mild conditions into supramolecular ... -
Spatial organization of functional groups on bioactive supramolecular glycopeptide nanofibers for differentiation of mesenchymal stem cells (MSCs) to brown adipogenesis
(American Chemical Society, 2016-12)Spatial organization of bioactive moieties in biological materials has significant impact on the function and efficiency of these systems. Here, we demonstrate the effect of spatial organization of functional groups including ... -
Surface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repair
(Taylor and Francis Ltd., 2016)The aim of the study is in vitro investigation of the feasibility of surface-modified bacterial nanofibrous poly [(R)-3-hydroxybutyrate] (PHB) graft for bladder reconstruction. In this study, the surface of electrospun ... -
Therapeutic nanomaterials for cartilage regeneration
(John Wiley & Sons, 2016-03-11)Articular cartilage (AC) is the main focus of this chapter and indeed most cartilage regeneration studies, since it is commonly affected by diseases and traumatic injuries that necessitate its therapeutic regeneration. ... -
Two-tier tissue decomposition for histopathological image representation and classification
(Institute of Electrical and Electronics Engineers, 2015)In digital pathology, devising effective image representations is crucial to design robust automated diagnosis systems. To this end, many studies have proposed to develop object-based representations, instead of directly ...
