Browsing by Keywords "TLR"
Now showing items 1-10 of 10
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Differential immune activation following encapsulation of immunostimulatory CpG oligodeoxynucleotide in nanoliposomes
(Elsevier, 2011)The immunogenicity of a vaccine formulation is closely related to the effective internalization by the innate immune cells that provide prolonged and simultaneous delivery of antigen and adjuvant to relevant antigen ... -
Enhanced immunomodulatory applications of nucleic acid encapsulating liposomes
(Bilkent University, 2009)Recent studies have demonstrated that innate immune system has great ability to discriminate self from non-self through the action of innate immune receptors. The most extensively studied innate immune receptor family ... -
Immunomodulatory effects of TLR ligands and polysaccharide combinations : strategies to augment innate immune response
(Bilkent University, 2007)Microbial infection initiates multiple TLR ligand mediated signaling cascade on innate immune cells. While some TLRs trigger a Th1 biased immune activation, others may lead to a Th2 dominant immune response. Extracellular ... -
Immunomodulatory potential of human umbilical cord tissue-derived mesenchymal stromal cell (UCX®) exosomes in combination with immunosuppressive “A151” oligodeoxynucleotide
(Bilkent University, 2019-08)Mesenchymal stromal or stem cells (MSCs) modulate immune responses apart from their regenerative capacities. Accumulating evidence suggests that MSCs exert their paracrine effects through extracellular vesicles known as ... -
Immunoregulatory activities of nanoparticle-forming oligodeoxynucleotides
(Bilkent University, 2009)Innate immune system is activated by a wide range of microbial by products leading to an immediate immune activation primarily designed to neutralize and control the invading insult. The cells of the innate immune system ... -
Immunostimulatory activity of polysaccharide-poly ( I: C ) nanoparticles
(Elsevier, 2011-06)Immunostimulatory properties of mushroom derived polysaccharides (PS) as stand-alone agents were tested. Next. PS were nanocomplexed with polyI:C (pIC) to yield stable nanoparticles around 200 nm in size evidenced by atomic ... -
Immunotherapeutic applications of nucleic acid based tlr agonists and antagonists
(Bilkent University, 2014)Recent evidence suggests that genetic material is not just the blueprint of life. Depending on the type of the source that genomic material is extracted or the type of motif that DNA harbors DNA could be immunostimulatory ... -
In vitro and in vivo immunomodulatory effects of extracellular vesicles
(Bilkent University, 2013)The major theme of this thesis was to characterize and understand the immunomodulatory potential of extracellular vesicles (EVs) isolated from different mouse and human cell lines on immune cells. To this end, we first ... -
In vivo applications of liposomal vaccines encapsulating single or dual pathogenassociated molecular patterns
(Bilkent University, 2017-03)Nucleic acid-based pattern recognition receptor (PRR) agonists are promising adjuvants and immunotherapeutic agents. Combination of PRR ligands potentiates immune response by providing synergistic immune activity via ... -
Suppressive oligodeoxynucleotides as a TLR antagonist : efforts to treat autoimmune diseases
(Bilkent University, 2007)Synthetic oligodeoxynucleotides (ODN) expressing suppressive TTAGGG motifs effectively down-regulate the production of proinflammatory and Th1 cytokines elicited by a variety of Toll-Like Receptor (TLR) dependent or ...
