Now showing items 1-4 of 4

    • Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio) 

      Karoglu, E. T.; Halim, D. O.; Erkaya, B.; Altaytas, F.; Arslan-Ergul, A.; Konu, O.; Adams, M. M. (Elsevier, 2017-06)
      The zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The ...
    • Aging, neurogenesis, and caloric restriction in different model organisms 

      Ergul, A. A.; Ozdemir A.T.; Adams, M. M. (International Society on Aging and Disease, 2013)
      Brain aging is a multifactorial process that is occurring across multiple cognitive domains. A significant complaint that occurs in the elderly is a decrement in learning and memory ability. Both rodents and zebrafish ...
    • Mammalian target of rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases 

      Celebi-Birand, Ergül Dilan; Karoğlu, Elif Tuğçe; Doldur-Ballı, Füsun; Adams, Michelle M. (Elsevier Inc., 2016)
      Normal aging is accompanied by cognitive impairment with subtle cellular and molecular changes in the brain, whereas, pathological brain aging manifests as severe behavioral impairments with cellular pathology. Understanding ...
    • Systematic discovery of Rab GTPases with synaptic functions in Drosophila 

      Chan, C.-C.; Scoggin, S.; Wang, D.; Cherry, S.; Dembo, T.; Greenberg, B.; Jin, E.J.; Kuey, C.; Lopez, A.; Mehta, S.Q.; Perkins, T.J.; Brankatschk, M.; Rothenfluh, A.; Buszczak, M.; Hiesinger P.R. (2011)
      Background: Neurons require highly specialized intracellular membrane trafficking, especially at synapses. Rab GTPases are considered master regulators of membrane trafficking in all cells, and only very few Rabs have known ...