Browsing by Keywords "Singlet oxygen"
Now showing items 1-20 of 21
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Activatable photosensitizers: agents for selective photodynamic therapy
(Wiley-VCH Verlag, 2017)Recent developments in the design of bifunctional and activatable photosensitizers rejuvenate the aging field of photodynamic sensitization and photodynamic therapy. While systematic studies have uncovered new dyes that ... -
A bifunctional photosensitizer for enhanced fractional photodynamic therapy: singlet oxygen generation in the presence and absence of light
(Wiley-VCH Verlag, 2016)The photosensitized generation of singlet oxygen within tumor tissues during photodynamic therapy (PDT) is self-limiting, as the already low oxygen concentrations within tumors is further diminished during the process. In ... -
Bodipy-based photosensitizers with long alkyl tails at the meso position: efficient singlet oxygen generation in Cremophor-EL micelles
(Elsevier Ltd, 2016)Bodipy dyes with n-decyloxyphenyl-(4, 5) and pentadecyl-(8) meso substituents can easily embed themselves into micellar structures formed from Cremophor-EL. In micelles of approximately 20 nm median size, heavy-atom ... -
“Clicked” Porphyrin-cucurbituril conjugate: a new multifunctional supramolecular assembly based on triglycosylated porphyrin and Monopropargyloxycucurbit[7]uril
(Wiley-VCH Verlag, 2018)The design, synthesis, and characterization of a new multifunctional supramolecular assembly based on a photoactive glycosylated porphyrin and covalently attached monofunctionalized cucurbit[7]uril (CB7) are reported. To ... -
Controlled singlet oxygen generation via plasmonic heating of gold nanorods
(Bilkent University, 2015-08)Photodynamic therapy (PDT) is the up-and-coming and developing methodology in order to treat various cancer tissues. The success of therapeutic action is directly related to the presence of cytotoxic singlet oxygen (SO) ... -
Designing excited states: theory-guided access to efficient photosensitizers for photodynamic action
(2011)The in silico design of tetraradical S 1 states was validated experimentally through synthesis, followed by characterization including phosphorescence measurements, use of trap molecules, and cell culture studies, leading ... -
Fluorescence detection of biological thiols and axially chiral bodipy derivatives and alternative methodologies for singlet oxygen generation for photodynamic action
(Bilkent University, 2014)Calorimetric and luminescent detection of biological thiols namely cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) have attracted great interest due to the their biological significance. There are many reported ... -
Generation, storage and delivery of singlet oxygen by a multifunctional agent
(Bilkent University, 2017-04)Photodynamic therapy (PDT) relies on thephoto sensitized generation of sin- glet oxygen (by consuming dissolved oxygen) within tumortissues whose oxygen level is already low enough to make this treatment self-limiting. In ... -
Iron oxide/silica core-shell nanoparticles as rechargeable sources of singlet oxygen for synthetic applications
(Bilkent University, 2017-04)In the rapidly developing world ofsynthetic chemistry, there is aconstant need for high-efficient catalyst. Besides this, reusable and easily removable catalysts are highly desired to reduce costs for environmentally ... -
Near-IR absorbing BODIPY derivatives as glutathione-activated photosensitizers for selective photodynamic action
(Wiley-VCH Verlag, 2014)Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and the practical applications of photodynamic therapy. Considering the high ... -
Near-IR-triggered, remote-controlled release of metal ions: A novel strategy for caged ions
(Wiley-VCH Verlag, 2014)A ligand incorporating a dithioethenyl moiety is cleaved into fragments which have a lower metal-ion affinity upon irradiation with low-energy red/near-IR light. The cleavage is a result of singlet oxygen generation ... -
Non-covalent functionalized SWNTs as delivery agents for novel Bodipy-based potential PDT sensitizers
(2009)Pyrenyl-functionalized distyryl-Bodipy sensitizer attached non-covalently to SWNTs was shown to generate singlet oxygen when excited at 660 nm with a red LED array; this work emphasizes the potential of SWNT as a viable ... -
Novel near-ir photosensitizers for photodynamic therapy and designing heavy atom free photosensitizers for the photodynamic therapy
(Bilkent University, 2016-03)Photodynamic therapy (PDT) is a promising and emerging noninvasive treatment modality for the treatment of a great number of malignant and non-malignant diseases. Therapeutic strategy in PDT is performed by combining a ... -
PEGylated calix[4]arene as a carrier for a Bodipy-based photosensitizer
(Elsevier, 2014)Heavy atom substituted Bodipy compounds, unlike the parent chromophore, undergo rapid intersystem crossing to generate singlet oxygen, which is the primary cytotoxic agent exploited in PDT. In this work, we show that an ... -
Remote-controlled release of singlet oxygen by the plasmonic heating of endoperoxide-modified gold nanorods: towards a paradigm change in photodynamic therapy
(Wiley-VCH Verlag, 2016)The photodynamic therapy of cancer is contingent upon the sustained generation of singlet oxygen in the tumor region. However, tumors of the most metastatic cancer types develop a region of severe hypoxia, which puts them ... -
Synthesis and characterization of cucurbituril based photoactive multifunctional assemblies
(Bilkent University, 2019-02)Preparation of cucurbituril based functional materials and their use in various applications ranging from biomedicine to optoelectronics have been studied intensely over the last decade. Supramolecular assemblies, networks ... -
Synthesis of BODIPY conjugates towards multimodal therapeutic applicaitons
(Bilkent University, 2016-09)Photodynamic therapy (PDT) is a promising and developing strategy to treat various types of cancers. Either on its own, or combined with surgical interference, it provides easy treatment without destructive side effects ... -
Synthesis of oligomers, polymers and cucurbituril- based polyrotaxanes towards polymer light emitting diode and photodynamic therapy application
(Bilkent University, 2014-06)In the first part of this study, porphyrin-thiophene monomers, oligomers and polymer are synthesized for photodynamic therapy application. Water solubility and the ability of a photosensitizer to generate singlet oxygen ... -
Tetrastyryl-BODIPY dyes as potential photosensitizers for photodynamic theraphy
(Bilkent University, 2011)Photodynamic therapy (PDT) is a novel methodology for a wide range of treatments of cancerous and noncancerous diseases. Success of treatment and photodynamic action is highly dependent the performance of PDT agents. Therefore, ... -
Thinking outside the silicon box: molecular and logic as an additional layer of selectivity in singlet oxygen generation for photodynamic therapy
(2009)A simple derivative of a well-known dye bodipy appears to be a satisfactory sensitizer for singlet oxygen. Moreover, the rate of singlet oxygen generation can be modulated by two cancer-related cellular parameters, sodium ...
