Browsing by Keywords "Sequencing"

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Assessment and correction of errors in DNA sequencing technologies

Fırtına, Can (Bilkent University, 2017-12)

Next Generation Sequencing technologies differ by several parameters where the choice to use whether short or long read sequencing platforms often leads to trade-offs between accuracy and read length. In this thesis, I ...
Bias correction in finding copy number variation with using read depth-based methods in exome sequencing data

Balcı, Fatma (Bilkent University, 2014)

Medical research has striven for identifying the causes of disorders with the ultimate goal of establishing therapeutic treatments and finding cures since its early years. This aim is now becoming a reality thanks to ...
The genetic structure of the Turkish population reveals high levels of variation and admixture

Kars, Meltem Ece; Başak, A. N.; Onat, Onur Emre; Bilguvar, K.; Choi, J.; Itan, Y.; Çağlar, C.; Palvadeau, R.; Casanova, J.-L.; Cooper, D. N.; Stenson, P. D.; Yavuz, A.; Buluş, H.; Günel, M.; Friedman, J. M.; Özçelik, Tayfun (National Academy of Sciences, 2020-12-18)

The construction of population-based variomes has contributed substantially to our understanding of the genetic basis of human inherited disease. Here, we investigated the genetic structure of Turkey from 3,362 unrelated ...